The role of biomolecular condensates in protein aggregation
There is an increasing amount of evidence that biomolecular condensates are linked to
neurodegenerative diseases associated with protein aggregation, such as Alzheimer's …
neurodegenerative diseases associated with protein aggregation, such as Alzheimer's …
Conformational dynamics of intrinsically disordered proteins regulate biomolecular condensate chemistry
Motions in biomolecules are critical for biochemical reactions. In cells, many biochemical
reactions are executed inside of biomolecular condensates formed by ultradynamic …
reactions are executed inside of biomolecular condensates formed by ultradynamic …
Extreme dynamics in a biomolecular condensate
Proteins and nucleic acids can phase-separate in the cell to form concentrated biomolecular
condensates,,–. The functions of condensates span many length scales: they modulate …
condensates,,–. The functions of condensates span many length scales: they modulate …
Interaction of mitochondria with the endoplasmic reticulum and plasma membrane in calcium homeostasis, lipid trafficking and mitochondrial structure
J Szymański, J Janikiewicz, B Michalska… - International Journal of …, 2017 - mdpi.com
Studying organelles in isolation has been proven to be indispensable for deciphering the
underlying mechanisms of molecular cell biology. However, observing organelles in intact …
underlying mechanisms of molecular cell biology. However, observing organelles in intact …
Impact of in‐cell and in‐vitro crowding on the conformations and dynamics of an intrinsically disordered protein
The conformations and dynamics of proteins can be influenced by crowding from the large
concentrations of macromolecules within cells. Intrinsically disordered proteins (IDPs) …
concentrations of macromolecules within cells. Intrinsically disordered proteins (IDPs) …
Nanoscale viscosity of cytoplasm is conserved in human cell lines
K Kwapiszewska, K Szczepański… - The journal of …, 2020 - ACS Publications
Metabolic reactions in living cells are limited by diffusion of reagents in the cytoplasm. Any
attempt to quantify the kinetics of biochemical reactions in the cytosol should be preceded by …
attempt to quantify the kinetics of biochemical reactions in the cytosol should be preceded by …
A unified description of intrinsically disordered protein dynamics under physiological conditions using NMR spectroscopy
Intrinsically disordered proteins (IDPs) are flexible biomolecules whose essential functions
are defined by their dynamic nature. Nuclear magnetic resonance (NMR) spectroscopy is …
are defined by their dynamic nature. Nuclear magnetic resonance (NMR) spectroscopy is …
Application of bacteriophages in nanotechnology
J Paczesny, K Bielec - Nanomaterials, 2020 - mdpi.com
Bacteriophages (phages for short) are viruses, which have bacteria as hosts. The single
phage body virion, is a colloidal particle, often possessing a dipole moment. As such …
phage body virion, is a colloidal particle, often possessing a dipole moment. As such …
NMR provides unique insight into the functional dynamics and interactions of intrinsically disordered proteins
AR Camacho-Zarco, V Schnapka, S Guseva… - Chemical …, 2022 - ACS Publications
Intrinsically disordered proteins are ubiquitous throughout all known proteomes, playing
essential roles in all aspects of cellular and extracellular biochemistry. To understand their …
essential roles in all aspects of cellular and extracellular biochemistry. To understand their …
Fast nanoparticle rotational and translational diffusion in synovial fluid and hyaluronic acid solutions
M Unni, S Savliwala, BD Partain… - Science …, 2021 - science.org
Nanoparticles are under investigation as diagnostic and therapeutic agents for joint
diseases, such as osteoarthritis. However, there is incomplete understanding of nanoparticle …
diseases, such as osteoarthritis. However, there is incomplete understanding of nanoparticle …