The inbred mouse strain C57BL/6 has been widely used as a background strain for
spontaneous and induced mutations. Developed in the 1930s, the C57BL/6 strain diverged …

Animal seizure and epilepsy models continue to play an important role in the early discovery
of new therapies for the symptomatic treatment of epilepsy. Since 1937, with the discovery of …

The pilocarpine animal model of status epilepticus is a well-established, clinically
translatable model that satisfies all of the criteria essential for an animal model of status …

Animal models of epilepsy and seizures, mostly involving mice and rats, are used to
understand the pathophysiology of the different forms of epilepsy and their comorbidities, to …

A refined kainate (KA) C57BL/6J mouse model of status epilepticus (SE) using a repeated
low dose (RLD) of KA (5 mg/kg, intraperitoneal; at 30 min intervals) was compared with the …

Many disease‐relevant phenotypes modeled in inbred mice have been shown to be strain‐
dependent, indicating the important influence of genetic background on disease …

The C57BL/6J mouse as a model of seizure/epilepsy is challenging due to high mortality
and huge variability in response to kainate. We have recently demonstrated that repeated …

It is becoming increasingly clear that the genetic background of mice and rats, even in
inbred strains, can have a profound influence on measures of seizure susceptibility and …

Objective Epilepsy affects 60 million people worldwide. Despite the development of
antiepileptic drugs, up to 35% of patients are drug refractory with uncontrollable seizures …

Postinjury epilepsy (PIE) is a devastating sequela of various brain insults. While recent
studies offer novel insights into the mechanisms underlying epileptogenesis and discover …