G-protein-coupled receptors (GPCRs) have been tractable drug targets for decades with
over one-third of currently marketed drugs targeting GPCRs. Of these, the class A GPCR …

Piperazine and homopiperazine are well-studied heterocycles in drug design that have
found gainful application as scaffolds and terminal elements and for enhancing the aqueous …

The first highly efficient and scalable cobalt‐catalyzed directed C H functionalization with
carbene precursors is presented. This methodology provides a modular route towards a new …

New chemo-and biocatalytic methodology is important for the future sustainable synthesis of
essential molecules. Transition metal catalysis enables the late-stage C− H functionalization …

The M1 and M4 muscarinic acetylcholine receptors (mAChRs) are highly pursued drug
targets for neurological diseases, in particular for Alzheimer's disease and schizophrenia …

Highlights•Dysfunction in glutamatergic and cholinergic signaling in schizophrenia is
discussed.•The advantages of allosteric modulation are discussed.•Activation of the M 1 …

Cognitive enhancers (nootropics) are drugs to treat cognition deficits in patients suffering
from Alzheimer's disease, schizophrenia, stroke, attention deficit hyperactivity disorder, or …

It is hypothesized that selective muscarinic M1 subtype activation could be a strategy to
provide cognitive benefits to schizophrenia and Alzheimer's disease patients while …

There is substantial evidence that cholinergic system function impairment plays a significant
role in many central nervous system (CNS) disorders. During the past three decades …

A Rh (III)-catalyzed oxidative annulation of pyridin-2 (1 H)-ones with alkynes via double C–H
activation to produce highly functionalized 4 H-quinolizin-4-ones is disclosed. This reaction …