Single-nucleus genomics in outbred rats with divergent cocaine addiction-like behaviors reveals changes in amygdala GABAergic inhibition
The amygdala processes positive and negative valence and contributes to addiction, but the
cell-type-specific gene regulatory programs involved are unknown. We generated an atlas of …
cell-type-specific gene regulatory programs involved are unknown. We generated an atlas of …
Analysis of the selective antagonist SAFit2 as a chemical probe for the FK506-binding protein 51
V Buffa, FH Knaup, T Heymann… - ACS Pharmacology & …, 2023 - ACS Publications
The FK506-binding protein 51 (FKBP51) has emerged as an important regulator of the
mammalian stress response and is involved in persistent pain states and metabolic …
mammalian stress response and is involved in persistent pain states and metabolic …
Chemogenetic inhibition of central amygdala CRF-expressing neurons decreases alcohol intake but not trauma-related behaviors in a rat model of post-traumatic …
Post-traumatic stress disorder (PTSD) and alcohol use disorder (AUD) are often comorbid.
Few treatments exist to reduce comorbid PTSD/AUD. Elucidating the mechanisms …
Few treatments exist to reduce comorbid PTSD/AUD. Elucidating the mechanisms …
IL-18 Signaling in the Rat Central Amygdala Is Disrupted in a Comorbid Model of Post-Traumatic Stress and Alcohol Use Disorder
Alcohol use disorder (AUD) and anxiety disorders are frequently comorbid and share
dysregulated neuroimmune-related pathways. Here, we used our established rat model of …
dysregulated neuroimmune-related pathways. Here, we used our established rat model of …
Alcohol-specific transcriptional dynamics of memory reconsolidation and relapse
K Goltseker, P Garay, K Bonefas, S Iwase… - Translational …, 2023 - nature.com
Relapse, a critical issue in alcohol addiction, can be attenuated by disruption of alcohol-
associated memories. Memories are thought to temporarily destabilize upon retrieval during …
associated memories. Memories are thought to temporarily destabilize upon retrieval during …
Sexually dimorphic effects of monoacylglycerol lipase inhibitor MJN110 on stress‐related behaviour and drinking in Marchigian Sardinian alcohol‐preferring rats
Abstract Background and Purpose The endocannabinoid (eCB) system plays an important
homeostatic role in the regulation of stress circuits and has emerged as a therapeutic target …
homeostatic role in the regulation of stress circuits and has emerged as a therapeutic target …
FK-binding protein 5: Possible relevance to the pathogenesis of metabolic dysfunction and alcohol-associated liver disease
The FK506-binding protein (FKBP5) plays significant roles in mediating stress responses by
interacting with glucocorticoids, participating in adipogenesis, and influencing various …
interacting with glucocorticoids, participating in adipogenesis, and influencing various …
Psilocybe cubensis extract potently prevents fear memory recall and freezing behavior in short-but not long-term in a rat model of posttraumatic stress disorder.
Z Ghofrani-Jahromi, S Nouri-Darehno… - Behavioral …, 2024 - psycnet.apa.org
Psilocybe cubensis is a species of psilocybin mushroom (magic mushroom) of moderate
potency whose principal active compounds are psilocybin and psilocin. Recent studies have …
potency whose principal active compounds are psilocybin and psilocin. Recent studies have …
MicroRNA hsa-miR-320a-3p and Its Targeted mRNA FKBP5 Were Differentially Expressed in Patients with HIV/TB Co-Infection
A Li, J Bao, S Gao, Y He, X Nie… - ACS Infectious …, 2023 - ACS Publications
Among the PLWH (people living with HIV) population, the risk of developing active
tuberculosis (TB) is increasing. Active TB also accelerates the deterioration of PLWH's …
tuberculosis (TB) is increasing. Active TB also accelerates the deterioration of PLWH's …
Protective effect of FKBP12 on dextran sulfate sodium-induced ulcerative colitis in mice as a tacrolimus receptor
B Wang, T Li, L Xu, Y Cai - Nucleosides, Nucleotides & Nucleic …, 2024 - Taylor & Francis
Ulcerative colitis (UC) is a multifactorial intestinal disease with a high incidence. In recent
years, there has been an urgent need for pleiotropic drugs with a clear biosafety profile …
years, there has been an urgent need for pleiotropic drugs with a clear biosafety profile …