As the organ with the highest demand for oxygen, the brain has a poor tolerance to ischemia
and hypoxia. Despite severe ischemia/hypoxia induces the occurrence and development of …

Over the past 50 years, intense research effort has taught us a great deal about multiple
sclerosis. We know that it is the most common neurological disease affecting the young …

The SARS-CoV-2 pandemic has inspired renewed interest in understanding the
fundamental pathology of acute respiratory distress syndrome (ARDS) following infection …

There is widespread interest in identifying interventions that extend healthy lifespan. Chronic
continuous hypoxia delays the onset of replicative senescence in cultured cells and extends …

Background Traumatic brain injury (TBI) is characterized by a primary mechanical injury and
a secondary injury associated with neuroinflammation, blood–brain barrier (BBB) disruption …

Central nervous system (CNS)-resident cells such as microglia, oligodendrocytes and
astrocytes are gaining increasing attention in respect to their contribution to CNS …

Chronic hypoxia leads to irreversible cognitive impairment, primarily due to hippocampal
neurodegeneration, for which the underlying mechanism remains poorly understood. We …

Cerebrovascular microcirculation is essential for maintaining the physiological functions of
the brain. The brain can be protected from stress injury by remodeling the microcirculation …

Remyelination and neurodegeneration prevention mitigate disability in Multiple Sclerosis
(MS). We have shown acute intermittent hypoxia (AIH) is a novel, non‐invasive and effective …

The central nervous system (CNS) parenchyma is enclosed and protected by a multilayered
system of cellular and acellular barriers, functionally separating glia and neurons from …