[HTML][HTML] Total-Body PET/CT: Challenges and Opportunities

C Mingels, KJ Chung, AR Pantel, A Rominger… - Seminars in Nuclear …, 2024 - Elsevier
Long-axial field-of-view (LAFOV) systems have changed the field of molecular imaging.
Since their introduction, many PET centers have installed these next-generation digital …

[HTML][HTML] Optimization-derived blood input function using a kernel method and its evaluation with total-body PET for brain parametric imaging

Y Zhu, Q Tran, Y Wang, RD Badawi, SR Cherry, J Qi… - Neuroimage, 2024 - Elsevier
Dynamic PET allows quantification of physiological parameters through tracer kinetic
modeling. For dynamic imaging of brain or head and neck cancer on conventional PET …

A blood-free modeling approach for the quantification of the blood-to-brain tracer exchange in TSPO PET imaging

L Maccioni, CM Michelle, L Brusaferri… - Frontiers in …, 2024 - frontiersin.org
Introduction Recent evidence suggests the blood-to-brain influx rate (K1) in TSPO PET
imaging as a promising biomarker of blood–brain barrier (BBB) permeability alterations …

Multimodal positron emission tomography (PET) imaging in non-oncologic musculoskeletal radiology

F Kogan, D Yoon, MG Teeter, AJ Chaudhari, L Hales… - Skeletal radiology, 2024 - Springer
Musculoskeletal (MSK) disorders are associated with large impacts on patient's pain and
quality of life. Conventional morphological imaging of tissue structure is limited in its ability to …

Validation of cardiac image-derived input functions for functional PET quantification

MB Reed, PA Handschuh, C Schmidt, M Murgaš… - European Journal of …, 2024 - Springer
Purpose Functional PET (fPET) is a novel technique for studying dynamic changes in brain
metabolism and neurotransmitter signaling. Accurate quantification of fPET relies on …

Determining the optimal pharmacokinetic modelling and simplified quantification method of [18F]AlF-P16-093 for patients with primary prostate cancer (PPCa)

R Zhao, Z Xia, M Ke, J Lv, H Zhong, Y He, D Gu… - European Journal of …, 2024 - Springer
Purpose This paper discusses the optimization of pharmacokinetic modelling and alternate
simplified quantification method for [18F] AlF-P16-093, a novel tracer for in vivo imaging of …

[HTML][HTML] Physically informed deep neural networks for metabolite-corrected plasma input function estimation in dynamic PET imaging

M Ferrante, M Inglese, L Brusaferri… - Computer methods and …, 2024 - Elsevier
Introduction: We propose a novel approach for the non-invasive quantification of dynamic
PET imaging data, focusing on the arterial input function (AIF) without the need for invasive …

Assessment of image-derived input functions from small vessels for patlak parametric imaging using total-body PET/CT

H Tang, Y Wu, Z Cheng, S Song, Q Dong… - European Journal of …, 2024 - Springer
Purpose The image-derived input function (IDIF) from the descending aorta has
demonstrated performance comparable to arterial blood sampling while avoiding its …

Quantitative PET imaging and modeling of molecular blood-brain barrier permeability

KJ Chung, YG Abdelhafez, BA Spencer, T Jones… - medRxiv, 2024 - pmc.ncbi.nlm.nih.gov
Blood-brain barrier (BBB) disruption is involved in the pathogenesis and progression of
many neurological and systemic diseases. Non-invasive assessment of BBB permeability in …

Automated extraction of the arterial input function from brain images for parametric PET studies

H Moradi, R Vashistha, S Ghosh, K O'Brien… - EJNMMI research, 2024 - Springer
Background Accurate measurement of the arterial input function (AIF) is crucial for
parametric PET studies, but the AIF is commonly derived from invasive arterial blood …