Current approaches and challenges for the metabolite profiling of complex natural extracts

JL Wolfender, G Marti, A Thomas, S Bertrand - Journal of Chromatography …, 2015 - Elsevier
Metabolite profiling is critical in many aspects of the life sciences, particularly natural product
research. Obtaining precise information on the chemical composition of complex natural …

Endophytic Penicillium species and their agricultural, biotechnological, and pharmaceutical applications

RMK Toghueo, FF Boyom - 3 Biotech, 2020 - Springer
Penicillium genus constituted by over 200 species is one of the largest and fascinating
groups of fungi, particularly well established as a source of antibiotics. Endophytic …

Screening for potential α-glucosidase and α-amylase inhibitory constituents from selected Vietnamese plants used to treat type 2 diabetes

BTD Trinh, D Staerk, AK Jäger - Journal of ethnopharmacology, 2016 - Elsevier
Ethnopharmacological relevance The 18 plant species investigated in this study have been
used as herbal antidiabetic remedies in Vietnamese traditional medicines. This study aimed …

Current status and contemporary approaches to the discovery of antitumor agents from higher plants

G Agarwal, PJB Carcache, EM Addo… - Biotechnology advances, 2020 - Elsevier
Higher plant constituents have afforded clinically available anticancer drugs. These include
both chemically unmodified small molecules and their synthetic derivatives currently used or …

Mass spectrometry-based technology and workflows for studying the chemistry of fungal endophyte derived bioactive compounds

P Gupta, A Verma, N Rai, AK Singh… - ACS Chemical …, 2021 - ACS Publications
Bioactive compounds have gained substantial attention in research and have conferred
great advancements in the industrial and pharmacological fields. Highly diverse fungi and …

High-resolution α-amylase assay combined with high-performance liquid chromatography–solid-phase extraction–nuclear magnetic resonance spectroscopy for …

L Okutan, KT Kongstad, AK Jäger… - Journal of agricultural …, 2014 - ACS Publications
Type 2 diabetes affects millions of people worldwide, and new improved drugs or functional
foods containing selective α-amylase inhibitors are needed for improved management of …

Recent advances in the applications of Wittig reaction in the total synthesis of natural products containing lactone, pyrone, and lactam as a scaffold

MM Heravi, M Ghanbarian, V Zadsirjan… - Monatshefte für Chemie …, 2019 - Springer
The Wittig reaction enables the synthesis of an alkene from the reaction of an aldehyde or
ketone with the ylide generated from a phosphonium salt. Undoubtedly, its usefulness in the …

The 3, 4-dioxygenated 5-hydroxy-4-aryl-quinolin-2 (1 H)-one alkaloids. Results of 20 years of research, uncovering a new family of natural products

SO Simonetti, EL Larghi, TS Kaufman - Natural product reports, 2016 - pubs.rsc.org
Covering: up to April 2016 Aspergillus and Penicillium are fungal species known to produce
a high diversity of secondary metabolites, many of them endowed with interesting bioactivity …

Identification of PTP1B and α-Glucosidase Inhibitory Serrulatanes from Eremophila spp. by Combined use of Dual High-Resolution PTP1B and α-Glucosidase …

SG Wubshet, Y Tahtah, AM Heskes… - Journal of Natural …, 2016 - ACS Publications
According to the International Diabetes Federation, type 2 diabetes (T2D) has reached
epidemic proportions, affecting more than 382 million people worldwide. Inhibition of protein …

Natural 3,4-dihydro-2(1h)-quinolinones- Part II: animal, bacterial, and fungal sources

S Khadem, RJ Marles - Natural Product Research, 2024 - Taylor & Francis
While natural products have undoubtedly played a pivotal role in drug discovery, their
potential as lead compounds has been hindered by challenges such as limited accessibility …