Excessive trabeculation, often referred to as “noncompacted” myocardium, has been
described at all ages, from the fetus to the adult. Current evidence for myocardial …

There is increasing evidence regarding the prevalence of genetic cardiomyopathies, for
which arrhythmias may be the first presentation. Ventricular and atrial arrhythmias …

Mechanisms by which specific histone modifications regulate distinct gene networks remain
little understood. We investigated how H3K79me2, a modification catalyzed by DOT1L and …

Renal interstitial fibrosis is the pathological basis of end-stage renal disease, in which the
heterogeneity of macrophages in renal microenvironment plays an important role. However …

Background The prevalence of type 2 diabetes mellitus (T2DM) has increased over the past
decades. Diabetic cardiomyopathy (DCM) is the leading cause of death in T2DM patients …

The mechanisms of cardiovascular diseases (CVDs) remain incompletely elucidated. Single-
cell RNA sequencing (scRNA-seq) has enabled the profiling of single-cell transcriptomes at …

The proper functioning of diverse biological systems depends on the spatial organization of
their cells, a critical factor for biological processes like shaping intricate tissue functions and …

Rationale: Jacobsen syndrome is a rare chromosomal disorder caused by deletions in the
long arm of human chromosome 11, resulting in multiple developmental defects including …

Current transcriptomics technologies, including bulk RNA-seq, single-cell RNA sequencing
(scRNA-seq), single-nucleus RNA-sequencing (snRNA-seq), and spatial transcriptomics …

The growth and maturation of the ventricular chamber require spatiotemporally precise
synergy between diverse cell types. Alternative splicing deeply affects the processes …