Immunotherapy has revolutionized the clinical management of many malignancies but is
infrequently associated with durable objective responses when used as a standalone …

Radiation nephropathy (RN) is a kidney injury induced by ionizing radiation. In a clinical
setting, ionizing radiation is used in radiotherapy (RT). The use and the intensity of radiation …

Purpose Ultra-high-dose-rate FLASH radiation therapy has been shown to minimize side
effects of irradiation in various organs while keeping antitumor efficacy. This property, called …

PURPOSE It remains controversial whether busulfan-based versus total body irradiation
(TBI)–based regimens have comparable outcomes in patients with acute lymphoblastic …

In cancer treatments, especially high-dose radiotherapy (HDRT) is applied. Patients
suffering from chronic inflammatory diseases benefit from low-dose radiation therapy …

Bone tissue engineering (BTE) has proven to be a promising strategy for bone defect repair.
Due to its excellent biological properties, gelatin methacrylate (GelMA) hydrogels have been …

Total body irradiation (TBI)-based conditioning is associated with superior leukemia-free
survival in children with ALL undergoing HSCT. However, the risk for subsequent malignant …

Radiotherapy is a commonly used conditioning regimen for bone marrow transplantation
(BMT). Cytotoxicity limits the use of this life-saving therapy, but the underlying mechanisms …

Conditioning regimens play a crucial role in preventing relapse of acute myeloid leukemia
(AML) following allogeneic hematopoietic cell transplantation (HCT). In early times …

Conditioning of the bone marrow prior to haematopoietic stem cell transplant is essential in
eradicating the primary cause of disease, facilitating donor cell engraftment and avoiding …