Metabolomics, or the comprehensive profiling of small molecule metabolites in cells, tissues,
or whole organisms, has undergone a rapid technological evolution in the past two decades …

Disturbances in cardiac metabolism underlie most cardiovascular diseases. Metabolomics,
one of the newer omics technologies, has emerged as a powerful tool for defining changes …

INTRODUCTION There is a dimension to postnatal human development that involves
assembly of microbial communities in different body habitats, including the gut. Children with …

Branched-chain amino acid (BCAA; valine, leucine and isoleucine) supplementation is often
beneficial to energy expenditure; however, increased circulating levels of BCAA are linked …

Branched-chain amino acids (BCAA) are strongly associated with dysregulated glucose and
lipid metabolism, but the underlying mechanisms are poorly understood. We report that …

INTRODUCTION As we come to appreciate how our microbial communities (microbiota)
assemble following birth, there is an opportunity to determine how this facet of our …

Metabolomic profiling of obese versus lean humans reveals a branched-chain amino acid
(BCAA)-related metabolite signature that is suggestive of increased catabolism of BCAA and …

Objective A branched-chain amino acid (BCAA)-related metabolic signature is strongly
associated with insulin resistance and predictive of incident diabetes and intervention …

The myocardium is metabolically flexible; however, impaired flexibility is associated with
cardiac dysfunction in conditions including diabetes and heart failure. The mitochondrial …

Caffeine is one of the world's most consumed drugs. Recently, several studies showed that
its consumption is associated with lower risk for nonalcoholic fatty liver disease (NAFLD), an …