RNA splicing is an essential process that governs many aspects of cellular proliferation,
survival, and differentiation. Considering the importance of RNA splicing in gene regulation …

Over the past decade there has been increased awareness of the potential role of
alternative splicing in the etiology of cancer. In particular, advances in RNA-Sequencing …

Molecular-glue degraders are small molecules that induce a specific interaction between an
E3 ligase and a target protein, resulting in the target proteolysis. The discovery of molecular …

The progression of precancerous lesions to malignancy is often accompanied by increasing
complexity of chromosomal alterations but how these alterations arise is poorly understood …

Simple Summary Alternative splicing is one of the most fabulous and important mechanism
in the cell. Alternative splicing is capable of generating many proteins from a single gene …

Alternative splicing (AS) is an important event that contributes to posttranscriptional gene
regulation. This process leads to several mature transcript variants with diverse …

Background PARP inhibitors are active in various tumour types beyond BRCA-mutant
cancers, but their activity and molecular correlates in colorectal cancer (CRC) are not well …

Alternative pre-mRNA splicing is a critical mechanism that generates multiple mRNA from a
single gene, thereby increasing the diversity of the proteome. Recent research has …

RNA splicing is the process of forming mature mRNA, which is an essential phase
necessary for gene expression and controls many aspects of cell proliferation, survival, and …

Although aberrant splicing events of genes are closely related to the development and
progression of colorectal cancer (CRC), the mapping of abnormal splicing events, especially …