Transition metals occupy an essential niche in biological systems. Their electrostatic
properties stabilize substrates or reaction intermediates in the active sites of enzymes, and …

Heme is an essential cofactor and signaling molecule required for virtually all aerobic life.
However, excess heme is cytotoxic. Therefore, heme must be safely transported and …

The highly contagious disease tuberculosis (TB) is caused by the bacterium Mycobacterium
tuberculosis (Mtb), which has been evolving drug resistance at an alarming rate. Like all …

Transition metal ions are essential micronutrients for all living organisms. In mammals, these
ions are often protein-bound and sequestered within cells, limiting their availability to …

Colon cancer is a major cause of cancer deaths in Western countries and is associated with
diets high in red meat. Heme, the iron-porphyrin pigment of red meat, induces cytotoxicity of …

Iron acquisition is critical for virulence of the human pathogenic fungus Cryptococcus
neoformans. The cryptococcal transcript for the extracellular mannoprotein Cig1 is highly …

Simple Summary Complex interactions between marine Gram-positive pathogens and fish
hosts in the marine environment can result in diseases of economically important finfish …

Iron is an essential nutrient for many bacteria. Since the metal is highly sequestered in host
tissues, bound predominantly to heme, pathogenic bacteria often take advantage of heme …

Background Corynebacterium glutamicum is generally regarded as a safe microorganism
and is used to produce many biochemicals, including l-glutamate. 5-Aminolevulinic acid …

All prokaryotes encode a panel of metal sensor or metalloregulatory proteins that govern the
expression of genes that allows an organism to quickly adapt to toxicity or deprivation of …