As the home of cellular genetic information, the nucleus has a critical role in determining cell
fate and function in response to various signals and stimuli. In addition to biochemical …

Lamins are intermediate filament proteins that form a scaffold, termed nuclear lamina, at the
nuclear periphery. A small fraction of lamins also localize throughout the nucleoplasm …

Mutations in lamins, which are ubiquitous nuclear intermediate filaments, lead to a variety of
disorders including muscular dystrophy and dilated cardiomyopathy. Lamins provide …

Localized protein synthesis requires assembly and transport of translationally silenced
ribonucleoprotein particles (RNPs), some of which are exceptionally large. Where in the cell …

In the cytosol, actin polymers, intermediate filaments and microtubules can anchor to cell
surface adhesions and interlink to form intricate networks. This cytoskeleton is anchored to …

Nuclear lamins are type V intermediate filament proteins that polymerize into complex
filamentous meshworks at the nuclear periphery and in less structured forms throughout the …

While actin was discovered in the nucleus over 50 years ago, research lagged for decades
due to strong skepticism. The revitalization of research into nuclear actin occurred after it …

Lamins are intermediate filament proteins that assemble into a meshwork underneath the
inner nuclear membrane, the nuclear lamina. Mutations in the LMNA gene, encoding lamins …

Prostate cancer (PC) remains the second most common cause of cancer-related death in
Western countries. A previous proteomics study suggested that the nuclear membrane …

Heterochromatin is a constituent of eukaryotic genomes with functions spanning from gene
expression silencing to constraining DNA replication and repair. Inside the nucleus …