Neutrophils are the most abundant myeloid cells in human blood and are emerging as
important regulators of cancer. However, their functional importance has often been …

Chronic inflammation fosters cancer development and progression and also modulates
tumor responses to anticancer therapies. Neutrophils are key effector cells in innate …

The colony-stimulating factors (CSFs) are a group of cytokines central to the hematopoiesis
of blood cells, the modulation of their functional responses, as well as the maintenance of …

Neutrophils are primary inflammatory cells and absolutely essential to protect the host
during the early phases of microbial infection. Their role in cancer is less clear. Current …

Recent studies have highlighted the functional capacity of neutrophils as powerful mediators
of tissue inflammation. Granule-packaged proteases and reactive oxygen intermediates …

Granulocyte colony stimulating factor (GCSF) can decrease mortality of patients undergo
chemotherapy through increasing neutrophil counts. Many strategies have been developed …

Bacillus anthracis edema toxin (ET), an adenylyl cyclase, is an important virulence factor that
contributes to anthrax disease. The role of ET in anthrax pathogenesis is, however, poorly …

Cytokine-induced neutrophil mobilization from the bone marrow to circulation is a critical
event in acute inflammation, but how it is accurately controlled remains poorly understood. In …

Chronic alcohol abuse is a systemic disorder and a risk factor for acute respiratory distress
syndrome (ARDS) and chronic obstructive pulmonary disease (COPD). A significant amount …

Accumulating evidence that granulocyte colony− stimulating factor (G-CSF), the key
hematopoietic growth factor of the myeloid lineage, not only represents a major component …