A strong cohort of evidence exists that supports the localisation of corneal stem cells at the
limbus. The distinguishing characteristics of limbal cells as stem cells include slow cycling …

Limbal stem cell deficiency (LSCD) is a clinical condition characterized by damage of
cornea limbal stem cells, which results in an impairment of corneal epithelium turnover and …

Purpose Single cell (sc) analyses of key embryonic, fetal and adult stages were performed to
generate a comprehensive single cell atlas of all the corneal and adjacent conjunctival cell …

To treat unilateral limbal stem cell (LSC) deficiency, we developed cultivated autologous
limbal epithelial cells (CALEC) using an innovative xenobiotic-free, serum-free, antibiotic …

Background Corneal renewal and repair are mediated by stem cells of the limbus, the
narrow zone between the cornea and the bulbar conjunctiva. Ocular burns may destroy the …

The integrity of the cornea, the most anterior part of the eye, is indispensable for vision. Forty-
five million individuals worldwide are bilaterally blind and another 135 million have severely …

Thymus is necessary for lifelong immunological tolerance and immunity. It displays a
distinctive epithelial complexity and undergoes age-dependent atrophy. Nonetheless, it also …

Region-related heterogeneity and state transitions of microglia are important for brain
development and neurological pathogenesis. However, regional specialization and state …

Purpose.: To investigate the expression and role of the Wnt signaling pathway in human
limbal stem cells (LSCs). Methods.: Total RNA was isolated from the human limbus and …

Stem cell (SC) division, deployment, and differentiation are processes that contribute to
corneal epithelial renewal. Until now studying the destiny of these cells in a living mammal …