G-protein-coupled receptors (GPCRs) are known to play central roles in the physiology of
many organisms. Members of this seven α-helical transmembrane protein family transduce …

Alcohol is a widely used and abused substance with numerous negative consequences for
human health and safety. Historically, alcohol's widespread, non-specific neurobiological …

Neurotransmitters often have multiple receptors that induce distinct responses in receiving
cells. Expression and localization of neurotransmitter receptors in individual neurons are …

G-protein coupled receptors (GPCRs) play important roles in cell biology and insects'
physiological processes, toxicological response and the development of insecticide …

Background Circadian clocks allow organisms to anticipate daily fluctuations in their
environment by driving rhythms in physiology and behavior. Inter-organismal differences in …

Drosophila melanogaster has become a significant model organism for alcohol research. In
flies, a rich variety of behaviors can be leveraged for identifying genes affecting alcohol …

Alcohol use disorder (AUD) exacts an immense toll on individuals, families, and society.
Genetic factors determine up to 60% of an individual's risk of developing problematic alcohol …

Dysregulated motivation to consume psychoactive substances leads to addictive behaviors
that often result in serious health consequences. Understanding the neuronal mechanisms …

Organisms respond to various environmental stressors by modulating physiology and
behavior to maintain homeostasis. Steroids and catecholamines are involved in the highly …

Male flies under the influence of ethanol display disinhibited courtship, which is augmented
with repeated ethanol exposures. We have previously shown that dopamine is important for …