Molecular mechanisms of chemo‐and radiotherapy resistance and the potential implications for cancer treatment
YP Liu, CC Zheng, YN Huang, ML He, WW Xu… - MedComm, 2021 - Wiley Online Library
Cancer is a leading cause of death worldwide. Surgery is the primary treatment approach for
cancer, but the survival rate is very low due to the rapid progression of the disease and …
cancer, but the survival rate is very low due to the rapid progression of the disease and …
A review on epidermal growth factor receptor's role in breast and non-small cell lung cancer
Epithelial growth factor receptor (EGFR) is a cell surface transmembrane receptor that
mediates the tyrosine signaling pathway to carry the extracellular messages inside the cell …
mediates the tyrosine signaling pathway to carry the extracellular messages inside the cell …
Network medicine for disease module identification and drug repurposing with the NeDRex platform
Traditional drug discovery faces a severe efficacy crisis. Repurposing of registered drugs
provides an alternative with lower costs and faster drug development timelines. However …
provides an alternative with lower costs and faster drug development timelines. However …
Therapeutic proteins
DS Dimitrov - Therapeutic Proteins: Methods and Protocols, 2012 - Springer
Protein-based therapeutics are highly successful in clinic and currently enjoy
unprecedented recognition of their potential. More than 100 genuine and similar number of …
unprecedented recognition of their potential. More than 100 genuine and similar number of …
Pharmacogenomic landscape of patient-derived tumor cells informs precision oncology therapy
Outcomes of anticancer therapy vary dramatically among patients due to diverse genetic
and molecular backgrounds, highlighting extensive intertumoral heterogeneity. The …
and molecular backgrounds, highlighting extensive intertumoral heterogeneity. The …
Targeting miRNAs involved in cancer stem cell and EMT regulation: An emerging concept in overcoming drug resistance
Z Wang, Y Li, A Ahmad, AS Azmi, D Kong… - Drug resistance …, 2010 - Elsevier
Although chemotherapy is an important therapeutic strategy for cancer treatment, it fails to
eliminate all tumor cells due to intrinsic or acquired drug resistance, which is the most …
eliminate all tumor cells due to intrinsic or acquired drug resistance, which is the most …
A novel 3D human glioblastoma cell culture system for modeling drug and radiation responses
N Gomez-Roman, K Stevenson, L Gilmour… - Neuro …, 2017 - academic.oup.com
Background. Glioblastoma (GBM) is the most common primary brain tumor, with dismal
prognosis. The failure of drug–radiation combinations with promising preclinical data to …
prognosis. The failure of drug–radiation combinations with promising preclinical data to …
Imaging of cancer cells and dictated cytotoxicity using aptamer‐guided hybridization chain reaction (HCR)‐Generated G‐Quadruplex chains
DNA nanotechnology provides powerful tools for developing cancer theranostics. Here we
introduce the autonomous surface‐nucleolin‐guided HCR that leads to the polymerization of …
introduce the autonomous surface‐nucleolin‐guided HCR that leads to the polymerization of …
Targeting Notch signaling pathway to overcome drug resistance for cancer therapy
Z Wang, Y Li, A Ahmad, AS Azmi, S Banerjee… - … et Biophysica Acta (BBA …, 2010 - Elsevier
Chemotherapy is an important therapeutic strategy for cancer treatment and remains the
mainstay for the management of human malignancies; however, chemotherapy fails to …
mainstay for the management of human malignancies; however, chemotherapy fails to …
[HTML][HTML] Molecular pathology of lung cancer: key to personalized medicine
L Cheng, RE Alexander, GT MacLennan… - Modern Pathology, 2012 - Elsevier
The majority of lung adenocarcinoma patients with epidermal growth factor receptor-(EGFR)
mutated or EML4–ALK rearrangement-positive tumors are sensitive to tyrosine kinase …
mutated or EML4–ALK rearrangement-positive tumors are sensitive to tyrosine kinase …