Molecular mechanisms of chemo‐and radiotherapy resistance and the potential implications for cancer treatment

YP Liu, CC Zheng, YN Huang, ML He, WW Xu… - MedComm, 2021 - Wiley Online Library
Cancer is a leading cause of death worldwide. Surgery is the primary treatment approach for
cancer, but the survival rate is very low due to the rapid progression of the disease and …

A review on epidermal growth factor receptor's role in breast and non-small cell lung cancer

V Subramaniyan, S Fuloria, G Gupta, DH Kumar… - Chemico-biological …, 2022 - Elsevier
Epithelial growth factor receptor (EGFR) is a cell surface transmembrane receptor that
mediates the tyrosine signaling pathway to carry the extracellular messages inside the cell …

Network medicine for disease module identification and drug repurposing with the NeDRex platform

S Sadegh, J Skelton, E Anastasi, J Bernett… - Nature …, 2021 - nature.com
Traditional drug discovery faces a severe efficacy crisis. Repurposing of registered drugs
provides an alternative with lower costs and faster drug development timelines. However …

Therapeutic proteins

DS Dimitrov - Therapeutic Proteins: Methods and Protocols, 2012 - Springer
Protein-based therapeutics are highly successful in clinic and currently enjoy
unprecedented recognition of their potential. More than 100 genuine and similar number of …

Pharmacogenomic landscape of patient-derived tumor cells informs precision oncology therapy

JK Lee, Z Liu, JK Sa, S Shin, J Wang, M Bordyuh… - Nature …, 2018 - nature.com
Outcomes of anticancer therapy vary dramatically among patients due to diverse genetic
and molecular backgrounds, highlighting extensive intertumoral heterogeneity. The …

Targeting miRNAs involved in cancer stem cell and EMT regulation: An emerging concept in overcoming drug resistance

Z Wang, Y Li, A Ahmad, AS Azmi, D Kong… - Drug resistance …, 2010 - Elsevier
Although chemotherapy is an important therapeutic strategy for cancer treatment, it fails to
eliminate all tumor cells due to intrinsic or acquired drug resistance, which is the most …

A novel 3D human glioblastoma cell culture system for modeling drug and radiation responses

N Gomez-Roman, K Stevenson, L Gilmour… - Neuro …, 2017 - academic.oup.com
Background. Glioblastoma (GBM) is the most common primary brain tumor, with dismal
prognosis. The failure of drug–radiation combinations with promising preclinical data to …

Imaging of cancer cells and dictated cytotoxicity using aptamer‐guided hybridization chain reaction (HCR)‐Generated G‐Quadruplex chains

AFJ Jou, YT Chou, I Willner, JA Ho - Angewandte Chemie, 2021 - Wiley Online Library
DNA nanotechnology provides powerful tools for developing cancer theranostics. Here we
introduce the autonomous surface‐nucleolin‐guided HCR that leads to the polymerization of …

Targeting Notch signaling pathway to overcome drug resistance for cancer therapy

Z Wang, Y Li, A Ahmad, AS Azmi, S Banerjee… - … et Biophysica Acta (BBA …, 2010 - Elsevier
Chemotherapy is an important therapeutic strategy for cancer treatment and remains the
mainstay for the management of human malignancies; however, chemotherapy fails to …

[HTML][HTML] Molecular pathology of lung cancer: key to personalized medicine

L Cheng, RE Alexander, GT MacLennan… - Modern Pathology, 2012 - Elsevier
The majority of lung adenocarcinoma patients with epidermal growth factor receptor-(EGFR)
mutated or EML4–ALK rearrangement-positive tumors are sensitive to tyrosine kinase …