Polo-like kinase 1 (PLK1) signaling in cancer and beyond
S Iliaki, R Beyaert, IS Afonina - Biochemical pharmacology, 2021 - Elsevier
PLK1 is an evolutionary conserved Ser/Thr kinase that is best known for its role in cell cycle
regulation and is expressed predominantly during the G2/S and M phase of the cell cycle …
regulation and is expressed predominantly during the G2/S and M phase of the cell cycle …
Polo-like kinase 1 inhibitors in human cancer therapy: development and therapeutic potential
Polo-like kinase 1 (PLK1) plays an important role in a variety of cellular functions, including
the regulation of mitosis, DNA replication, autophagy, and the epithelial–mesenchymal …
the regulation of mitosis, DNA replication, autophagy, and the epithelial–mesenchymal …
RHINO directs MMEJ to repair DNA breaks in mitosis
Nonhomologous end-joining (NHEJ) and homologous recombination (HR) are the primary
pathways for repairing DNA double-strand breaks (DSBs) during interphase, whereas …
pathways for repairing DNA double-strand breaks (DSBs) during interphase, whereas …
[HTML][HTML] Identification of potent inhibitors of NEK7 protein using a comprehensive computational approach
NIMA related Kinases (NEK7) plays an important role in spindle assembly and mitotic
division of the cell. Over expression of NEK7 leads to the progression of different cancers …
division of the cell. Over expression of NEK7 leads to the progression of different cancers …
Polo-like kinases: structural variations lead to multiple functions
Members of the polo-like kinase (PLK) family are crucial regulators of cell cycle progression,
centriole duplication, mitosis, cytokinesis and the DNA damage response. PLKs undergo …
centriole duplication, mitosis, cytokinesis and the DNA damage response. PLKs undergo …
Mechanisms of specificity in protein phosphorylation
JA Ubersax, JE Ferrell Jr - Nature reviews Molecular cell biology, 2007 - nature.com
A typical protein kinase must recognize between one and a few hundred bona fide
phosphorylation sites in a background of∼ 700,000 potentially phosphorylatable residues …
phosphorylation sites in a background of∼ 700,000 potentially phosphorylatable residues …
Multifaceted polo-like kinases: drug targets and antitargets for cancer therapy
K Strebhardt - Nature reviews Drug discovery, 2010 - nature.com
The polo-like kinase 1 (PLK1) acts in concert with cyclin-dependent kinase 1–cyclin B1 and
Aurora kinases to orchestrate a wide range of critical cell cycle events. Because PLK1 has …
Aurora kinases to orchestrate a wide range of critical cell cycle events. Because PLK1 has …
Shared and separate functions of polo-like kinases and aurora kinases in cancer
Large numbers of inhibitors for polo-like kinases and aurora kinases are currently being
evaluated as anticancer drugs. Interest in these drugs is fuelled by the idea that these …
evaluated as anticancer drugs. Interest in these drugs is fuelled by the idea that these …
Polo-like kinases and the orchestration of cell division
Polo-like kinases (Plks) are increasingly recognized as key regulators of mitosis, meiosis
and cytokinesis. In agreement with a broad range of proposed functions during cell division …
and cytokinesis. In agreement with a broad range of proposed functions during cell division …
Aurora-PLK1 cascades as key signaling modules in the regulation of mitosis
V Joukov, A De Nicolo - Science signaling, 2018 - science.org
Mitosis is controlled by reversible protein phosphorylation involving specific kinases and
phosphatases. A handful of major mitotic protein kinases, such as the cyclin B–CDK1 …
phosphatases. A handful of major mitotic protein kinases, such as the cyclin B–CDK1 …