SWI/SNF chromatin remodeling complexes and cancer
JA Biegel, TM Busse… - American Journal of …, 2014 - Wiley Online Library
The identification of mutations and deletions in the SMARCB1 locus in chromosome band
22q11. 2 in pediatric rhabdoid tumors provided the first evidence for the involvement of the …
22q11. 2 in pediatric rhabdoid tumors provided the first evidence for the involvement of the …
The BRG1 ATPase of human SWI/SNF chromatin remodeling enzymes as a driver of cancer
Q Wu, JB Lian, JL Stein, GS Stein, JA Nickerson… - …, 2017 - Taylor & Francis
Mammalian SWI/SNF enzymes are ATP-dependent remodelers of chromatin structure.
These multisubunit enzymes are heterogeneous in composition; there are two catalytic …
These multisubunit enzymes are heterogeneous in composition; there are two catalytic …
Small cell carcinoma of the ovary, hypercalcemic type, displays frequent inactivating germline and somatic mutations in SMARCA4
Small cell carcinoma of the ovary of hypercalcemic type (SCCOHT) is an extremely rare,
aggressive cancer affecting children and young women. We identified germline and somatic …
aggressive cancer affecting children and young women. We identified germline and somatic …
BRG1 is a prognostic marker and potential therapeutic target in human breast cancer
BRG1, a core component of the SWI/SNF chromatin-remodeling complex, has been
implicated in cancer development; however, the biological significance of BRG1 in breast …
implicated in cancer development; however, the biological significance of BRG1 in breast …
SWI/SNF complex mutations in gynecologic cancers: molecular mechanisms and models
The SWI/SNF (mating type SWIt ch/Sucrose NonFermentable) chromatin remodeling
complexes interact with histones and transcription factors to modulate chromatin structure …
complexes interact with histones and transcription factors to modulate chromatin structure …
BRM: the core ATPase subunit of SWI/SNF chromatin-remodelling complex—a tumour suppressor or tumour-promoting factor?
BRM (BRAHMA) is a core, SWI2/SNF2-type ATPase subunit of SWI/SNF chromatin-
remodelling complex (CRC) involved in various important regulatory processes including …
remodelling complex (CRC) involved in various important regulatory processes including …
The SWI/SNF ATPases are required for triple negative breast cancer cell proliferation
The Brahma (BRM) and Brahma‐related Gene 1 (BRG1) ATPases are highly conserved
homologs that catalyze the chromatin remodeling functions of the multi‐subunit human …
homologs that catalyze the chromatin remodeling functions of the multi‐subunit human …
Remodeling the cancer epigenome: mutations in the SWI/SNF complex offer new therapeutic opportunities
KA Orlando, V Nguyen, JR Raab… - Expert review of …, 2019 - Taylor & Francis
Introduction: Cancer genome sequencing studies have discovered mutations in members of
the SWItch/Sucrose Non-Fermentable (SWI/SNF) chromatin-remodeling complex in nearly …
the SWItch/Sucrose Non-Fermentable (SWI/SNF) chromatin-remodeling complex in nearly …
Nuclear shape changes are induced by knockdown of the SWI/SNF ATPase BRG1 and are independent of cytoskeletal connections
KM Imbalzano, N Cohet, Q Wu, JM Underwood… - PloS one, 2013 - journals.plos.org
Changes in nuclear morphology occur during normal development and have been observed
during the progression of several diseases. The shape of a nucleus is governed by the …
during the progression of several diseases. The shape of a nucleus is governed by the …
[HTML][HTML] SWI/SNF complexes are required for full activation of the DNA-damage response
SL Smith-Roe, J Nakamura, D Holley, PD Chastain… - Oncotarget, 2015 - ncbi.nlm.nih.gov
Abstract SWI/SNF complexes utilize BRG1 (also known as SMARCA4) or BRM (also known
as SMARCA2) as alternative catalytic subunits with ATPase activity to remodel chromatin …
as SMARCA2) as alternative catalytic subunits with ATPase activity to remodel chromatin …