Decades of research have characterized diverse immune cells surveilling the CNS. More
recently, the discovery of osseous channels (so-called 'skull channels') connecting the …

Since its recent discovery, the meningeal lymphatic system has reshaped our understanding
of central nervous system (CNS) fluid exchange, waste clearance, immune cell trafficking …

Cerebrospinal fluid (CSF) in the subarachnoid space around the brain has long been known
to drain through the lymphatics to cervical lymph nodes,,,,,,,,,,,,,,,–, but the connections and …

The central nervous system (CNS) tightly regulates access of circulating immune cells.
Immunosurveillance is therefore managed in the meninges at the borders of the CNS. Here …

The brain, long thought to be isolated from the peripheral immune system, is increasingly
recognized to be integrated into a systemic immunological network. These conduits of …

In recent decades there has been a large focus on understanding the mechanisms of
peripheral immune cell infiltration into the central nervous system (CNS) in …

The meningeal space is a critical brain structure providing immunosurveillance for the
central nervous system (CNS), but the impact of infections on the meningeal immune …

Lymphatic transport maintains homeostatic health and is necessary for immune surveillance,
and yet lymphatic growth is often associated with solid tumour development and …

Crosstalk between central nervous system (CNS) and systemic responses is important in
many pathological conditions, including stroke, neurodegeneration, schizophrenia, epilepsy …

Discovery of meningeal lymphatic vessels (LVs) in the dura mater, also known as dural LVs
(dLVs) that depend on vascular endothelial growth factor C expression, has raised interest …