Apoptosis, necroptosis, and pyroptosis are genetically programmed cell death mechanisms
that eliminate obsolete, damaged, infected, and self-reactive cells. Apoptosis fragments cells …

Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated
guidelines for the definition and interpretation of cell death from morphological, biochemical …

Roles for cell death in development, homeostasis, and the control of infections and cancer
have long been recognized. Although excessive cell damage results in passive necrosis …

Mixed lineage kinase domain-like (MLKL) is the terminal protein in the pro-inflammatory
necroptotic cell death program. RIPK3-mediated phosphorylation is thought to initiate MLKL …

Cell death plays an important role during pathogen infections. Here, we report that interferon-
γ (IFNγ) sensitizes macrophages to Toll-like receptor (TLR)-induced death that requires …

Rewiring of host cytokine networks is a key feature of inflammatory bowel diseases (IBD)
such as Crohn's disease (CD). Th1-type cytokines—IFN-γ and TNF-α—occupy critical nodes …

Most metastatic cancers remain incurable due to the emergence of apoptosis-resistant
clones, fuelled by intratumour heterogeneity and tumour evolution. To improve treatment …

Caspases belong to a diverse clan of proteolytic enzymes known as clan CD with highly
disparate functions in cell signaling. The caspase members of this clan are only found in …

Mutant TP53 proteins are thought to drive the development and sustained expansion of
cancers at least in part through the loss of the wild-type (wt) TP53 tumour suppressive …

MLKL is the essential effector of necroptosis, a form of programmed lytic cell death. We have
isolated a mouse strain with a single missense mutation, Mlkl D139V, that alters the two …