Osteoarthritis (OA) is a disabling condition that affects billions of people worldwide and
places a considerable burden on patients and on society owing to its prevalence and …

Osteoarthritis (OA), is a major cause of severe joint pain, physical disability and quality of life
impairment in the aging population across the developed and developing world. Increased …

The role of native (not culture-expanded) joint-resident mesenchymal stem cells (MSCs) in
the repair of joint damage in osteoarthritis (OA) is poorly understood. MSCs differ from bone …

Obesity-related osteoarthritis (OA) is a complex, multifactorial condition that can cause
significant impact on patients' quality of life. Whilst chronic inflammation, adipocytokines and …

Objective To evaluate the efficacy and safety of intraarticular sprifermin (recombinant human
fibroblast growth factor 18) in the treatment of symptomatic knee osteoarthritis (OA). Methods …

There is emerging awareness that subchondral bone remodeling plays an important role in
the development of osteoarthritis (OA). This review presents recent investigations on the …

Joint distraction, the prolonged mechanical separation of the bones at a joint, has emerged
as a joint-preserving treatment for end-stage osteoarthritis, with the gradually growing …

Objective To summarize recent scientific advances in protein-derived soluble biomarkers of
osteoarthritis. Design A systematic search on the PubMed electronic database of clinical …

Background Treatment of severe osteoarthritis (OA) in relatively young patients is
challenging. Although successful, total knee prosthesis has a limited lifespan, with the risk of …

Osteoarthritis (OA) is the most prevalent joint disorder with no approved disease-modifying
treatment available. The importance of imaging in assessing all joint structures involved in …