Microtubules have long been considered an ideal target for anticancer drugs because of the
essential role they play in mitosis, forming the dynamic spindle apparatus. As such, there is …

Given its manifold potential therapeutic applications and amenability to modification,
noscapine is a veritable “Renaissance drug” worthy of commemoration. Perhaps the only …

Here, we introduce an engineered, tunable genetic switch that couples repressor proteins
and an RNAi target design to effectively turn any gene off. We used the switch to regulate the …

Drug delivery systems such as nanoparticles can provide enhanced efficacy for anticancer
agents. Noscapine, a widely used cough suppressant for decades has recently been shown …

Noscapine is an isoqiunoline alkaloid found in opium latex. Unlike most other alkaloids
obtained from opium latex, noscapine is not sedative and has been used as antitussive drug …

Background The aim of this study was to investigate the anticancer activity and mechanism
of action of Noscapine alone and in combination with Doxorubicin against triple negative …

In present investigation, an attempt was undertaken to modify the C-9 position of noscapine
(Nos), an opium alkaloid to yield 9-hydroxy methyl and 9-carbaldehyde oxime analogues for …

Bromo-noscapine (9-Br-Nos) alters tubulin polymerization in non-small cell lung cancer cells
differently from noscapine. However, clinical applications of 9-Br-Nos are limited owing to …

This review is an attempt to assess the different classes of phytochemicals and some of their
members which have been encapsulated into nanocarrier systems for their …

Autophagy is being increasingly implicated in both cell survival and death. However, the
intricate relationships between drug-induced autophagy and apoptosis remain elusive. Here …