The available evidence suggests a complex relationship between diabetes and cancer.
Epidemiological data suggest a positive correlation, however, in certain types of cancer, a …

Breast cancer (BC) is one of the most common cancers in women worldwide. Even though
the role of estrogen receptor alpha (ERα) is extensively documented in the development of …

Metastatic prostate cancer is characterized by recurrent genomic copy number alterations
that are presumed to contribute to resistance to hormone therapy. We identified CHD1 loss …

Simple Summary The study discusses the potential of targeting transcription factors (TFs) for
cancer therapy and provide a systematic classification of various types of TFs involved in the …

Glucocorticoids (GCs) are anti-inflammatory and immunosuppressive steroid molecules
secreted by the adrenal gland and regulated by the hypothalamic–pituitary–adrenal (HPA) …

Diabetic nephropathy (DN) is the main cause of end-stage renal disease (ESRD), which is
characterized by a series of abnormal changes such as glomerulosclerosis, podocyte loss …

Abstract Glucocorticoids (GCs), mostly dexamethasone (dex), are routinely administered as
adjuvant therapy to manage side effects in breast cancer. However, recently, it has been …

Simple Summary Early-stage invasive lobular breast cancer (ILC) is characterized by
multifocal tumor growth in the breast and a distinct pattern of late metastatic spread to other …

Hormonal signaling plays key roles in tissue and metabolic homeostasis. Accumulated
evidence has revealed a great deal of insulin and estrogen signaling pathways and their …

Simple Summary In solid tumours, emerging evidence indicates that signalling through the
glucocorticoid receptor (GR) can encourage the growth and spread of tumours and so drugs …