The mammalian ionotropic glutamate receptor family encodes 18 gene products that
coassemble to form ligand-gated ion channels containing an agonist recognition site, a …

Although recent technical advances in thrombectomy have revolutionised acute stroke
treatment, prevalence of disability and death related to stroke remain high. Therefore …

Thrombolysis with tissue-type plasminogen activator (tPA) is used for the treatment of
patients with acute ischemic stroke. However, a growing body of evidence indicates that …

Nanotechnology is an area of growing public interest. Its attractiveness stems from the
promise offered socially and economically by the recent significant advances in …

The excitatory neurotransmission of the central nervous system (CNS) mainly involves
glutamate and its receptors, especially N-methyl-D-Aspartate receptors (NMDARs). These …

Apolipoprotein B (apoB)–lipoproteins initiate and promote atherosclerotic cardiovascular
disease. Plasma tissue plasminogen activator (tPA) activity is negatively associated with …

Tissue-type plasminogen activator (tPA) a serine protease is constituted of five functional
domains through which it interacts with different substrates, binding proteins, and receptors …

We all know about classical fibrinolysis, how plasminogen activation by either tissue‐type
plasminogen activator (t‐PA) or urokinase‐type plasminogen activator (u‐PA) promotes …

The fibrinolytic system, known for its ability to regulate the activation of the zymogen
plasminogen into active plasmin, has been primarily associated with the removal of fibrin …

Tissue-type plasminogen activator (t-PA) can modulate permeability of the neurovascular
unit and exacerbate injury in ischemic stroke. We examined the effects of t-PA using in vitro …