Ultrahigh-Throughput Enzyme Engineering and Discovery in In Vitro Compartments
Novel and improved biocatalysts are increasingly sourced from libraries via experimental
screening. The success of such campaigns is crucially dependent on the number of …
screening. The success of such campaigns is crucially dependent on the number of …
Recent advances in droplet microfluidics
Y Ding, PD Howes, AJ deMello - Analytical chemistry, 2019 - ACS Publications
Prominent within this technology set are droplet-based microfluidic systems, 3 in which
passive microfluidic structures are used to rapidly generate and manipulate subnanoliter …
passive microfluidic structures are used to rapidly generate and manipulate subnanoliter …
Materials and methods for droplet microfluidic device fabrication
Since the first reports two decades ago, droplet-based systems have emerged as a
compelling tool for microbiological and (bio) chemical science, with droplet flow providing …
compelling tool for microbiological and (bio) chemical science, with droplet flow providing …
Speeding up enzyme discovery and engineering with ultrahigh-throughput methods
HA Bunzel, X Garrabou, M Pott, D Hilvert - Current opinion in structural …, 2018 - Elsevier
Exploring the sequence space of enzyme catalysts is ultimately a numbers game. Ultrahigh-
throughput screening methods for rapid analysis of millions of variants are therefore …
throughput screening methods for rapid analysis of millions of variants are therefore …
Recent advances in the design of microfluidic technologies for the manufacture of drug releasing particles
Drug releasing particles are valued for their ability to deliver therapeutics to targeted
locations and for their controllable release patterns. The development of microfluidic …
locations and for their controllable release patterns. The development of microfluidic …
Simple and precise counting of viable bacteria by resazurin-amplified picoarray detection
Simple, fast, and precise counting of viable bacteria is fundamental to a variety of
microbiological applications such as food quality monitoring and clinical diagnosis. To this …
microbiological applications such as food quality monitoring and clinical diagnosis. To this …
Microfluidic technologies for drug discovery and development: friend or foe?
KS Elvira - Trends in Pharmacological Sciences, 2021 - cell.com
There is a point in the evolution of every new technology when questions need to be asked
regarding its usefulness and impact. Although microfluidic technologies have drastically …
regarding its usefulness and impact. Although microfluidic technologies have drastically …
A programmable and automated optical electrowetting-on-dielectric (oEWOD) driven platform for massively parallel and sequential processing of single cell assay …
LG Welch, J Estranero, P Tourlomousis, RCR Wootton… - Lab on a Chip, 2024 - pubs.rsc.org
Recently, there has been an increasing emphasis on single cell profiling for high-throughput
screening workflows in drug discovery and life sciences research. However, the biology …
screening workflows in drug discovery and life sciences research. However, the biology …
From single-molecule detection to next-generation sequencing: microfluidic droplets for high-throughput nucleic acid analysis
Y Ding, J Choo, AJ DeMello - Microfluidics and nanofluidics, 2017 - Springer
Droplet-based microfluidic technologies have proved themselves to be of significant utility in
the performance of high-throughput chemical and biological experiments. By encapsulating …
the performance of high-throughput chemical and biological experiments. By encapsulating …
Microfluidic technique for the simultaneous quantification of emulsion instabilities and lipid digestion kinetics
N Scheuble, A Iles, RCR Wootton, EJ Windhab… - Analytical …, 2017 - ACS Publications
Quantifying the impact of environmental physicochemical changes on the microstructure of
lipid delivery systems is challenging. Therefore, we have developed a methodology to …
lipid delivery systems is challenging. Therefore, we have developed a methodology to …