Extracellular signal-regulated protein kinase 1/2 (ERK1/2), the only known substrate of
MEK1/2, is located downstream of the RAS-RAF-MEK-ERK (MAPK) pathway and is …

The p38 mitogen-activated protein kinase (p38MAPK, termed here p38) cascade is a central
signaling pathway that transmits stress and other signals to various intracellular targets in …

The SARS‐CoV‐2 makes its way into the cell via the ACE2 receptor and the proteolytic
action of TMPRSS2. In response to the SARS‐CoV‐2 infection, the innate immune response …

Metribuzin and tebuconazole have been widely used in agriculture for several decades.
Apart from endocrine disruption, little is known about their toxicological effects on organisms …

In recent decades, various investigations have indicated that natural compounds have great
potential in the prevention and treatment of different chronic disorders including different …

Radiotherapy is a frequent mode of cancer treatment, although the development of
radioresistance limits its effectiveness. Extensive investigations indicate the diversity of the …

Aim Resistance exercise increases muscle mass over time. However, the early signalling
events leading to muscle growth are not yet well‐defined. Here, we aim to identify new …

DNA damage–mediated activation of extracellular signal–regulated kinase (ERK) can
regulate both cell survival and cell death. We show here that ERK activation in this context is …

The ability of glutamatergic synaptic strength to change in response to prevailing neuronal
activity is believed to underlie the capacity of animals, including humans, to learn from …

To identify signaling pathways activated by oxycodone self-administration (SA), Sprague–
Dawley rats self-administered oxycodone for 20 days using short—(ShA, 3 h) and long …