Targeting extracellular signal-regulated protein kinase 1/2 (ERK1/2) in cancer: an update on pharmacological small-molecule inhibitors
L Fu, S Chen, G He, Y Chen, B Liu - Journal of medicinal chemistry, 2022 - ACS Publications
Extracellular signal-regulated protein kinase 1/2 (ERK1/2), the only known substrate of
MEK1/2, is located downstream of the RAS-RAF-MEK-ERK (MAPK) pathway and is …
MEK1/2, is located downstream of the RAS-RAF-MEK-ERK (MAPK) pathway and is …
[HTML][HTML] Nuclear P38: roles in physiological and pathological processes and regulation of nuclear translocation
G Maik-Rachline, L Lifshits, R Seger - International journal of molecular …, 2020 - mdpi.com
The p38 mitogen-activated protein kinase (p38MAPK, termed here p38) cascade is a central
signaling pathway that transmits stress and other signals to various intracellular targets in …
signaling pathway that transmits stress and other signals to various intracellular targets in …
SARS‐CoV‐2 multifaceted interaction with the human host. Part II: Innate immunity response, immunopathology, and epigenetics
TH Beacon, RC Su, TM Lakowski, GP Delcuve… - IUBMB …, 2020 - Wiley Online Library
The SARS‐CoV‐2 makes its way into the cell via the ACE2 receptor and the proteolytic
action of TMPRSS2. In response to the SARS‐CoV‐2 infection, the innate immune response …
action of TMPRSS2. In response to the SARS‐CoV‐2 infection, the innate immune response …
[HTML][HTML] Potential neurotoxicity, immunotoxicity, and carcinogenicity induced by metribuzin and tebuconazole exposure in earthworms (Eisenia fetida) revealed by …
G Li, D Li, H Rao, X Liu - Science of The Total Environment, 2022 - Elsevier
Metribuzin and tebuconazole have been widely used in agriculture for several decades.
Apart from endocrine disruption, little is known about their toxicological effects on organisms …
Apart from endocrine disruption, little is known about their toxicological effects on organisms …
Quercetin modulates signal transductions and targets non-coding RNAs against cancer development
In recent decades, various investigations have indicated that natural compounds have great
potential in the prevention and treatment of different chronic disorders including different …
potential in the prevention and treatment of different chronic disorders including different …
[HTML][HTML] Extracellular signal-regulated kinase 5 increases radioresistance of lung cancer cells by enhancing the DNA damage response
W Jiang, G Jin, F Cai, X Chen, N Cao… - … & Molecular Medicine, 2019 - nature.com
Radiotherapy is a frequent mode of cancer treatment, although the development of
radioresistance limits its effectiveness. Extensive investigations indicate the diversity of the …
radioresistance limits its effectiveness. Extensive investigations indicate the diversity of the …
Exercise‐dependent increases in protein synthesis are accompanied by chromatin modifications and increased MRTF‐SRF signalling
Aim Resistance exercise increases muscle mass over time. However, the early signalling
events leading to muscle growth are not yet well‐defined. Here, we aim to identify new …
events leading to muscle growth are not yet well‐defined. Here, we aim to identify new …
[HTML][HTML] EGF receptor and PKCδ kinase activate DNA damage–induced pro-survival and pro-apoptotic signaling via biphasic activation of ERK and MSK1 kinases
AM Ohm, T Affandi, ME Reyland - Journal of Biological Chemistry, 2019 - ASBMB
DNA damage–mediated activation of extracellular signal–regulated kinase (ERK) can
regulate both cell survival and cell death. We show here that ERK activation in this context is …
regulate both cell survival and cell death. We show here that ERK activation in this context is …
The influence of sensory experience on the glutamatergic synapse
DD Cooper, BG Frenguelli - Neuropharmacology, 2021 - Elsevier
The ability of glutamatergic synaptic strength to change in response to prevailing neuronal
activity is believed to underlie the capacity of animals, including humans, to learn from …
activity is believed to underlie the capacity of animals, including humans, to learn from …
[HTML][HTML] Oxycodone self-administration activates the mitogen-activated protein kinase/mitogen-and stress-activated protein kinase (MAPK-MSK) signaling pathway in …
To identify signaling pathways activated by oxycodone self-administration (SA), Sprague–
Dawley rats self-administered oxycodone for 20 days using short—(ShA, 3 h) and long …
Dawley rats self-administered oxycodone for 20 days using short—(ShA, 3 h) and long …