Therapeutic implications of caffeic acid in cancer and neurological diseases
Caffeic acid (CA) is found abundantly in fruits, vegetables, tea, coffee, oils, and more. CA
and its derivatives have been used for many centuries due to their natural healing and …
and its derivatives have been used for many centuries due to their natural healing and …
Biomedical features and therapeutic potential of rosmarinic acid
For decades, the use of secondary metabolites of various herbs has been an attractive
strategy in combating human diseases. Rosmarinic acid (RA) is a bioactive phenolic …
strategy in combating human diseases. Rosmarinic acid (RA) is a bioactive phenolic …
Targeting the NRF2/KEAP1 pathway in cervical and endometrial cancers
G Tossetta, D Marzioni - European Journal of Pharmacology, 2023 - Elsevier
Cervical and endometrial cancers are among the most dangerous gynaecological
malignancies, with high fatality and recurrence rates due to frequent diagnosis at an …
malignancies, with high fatality and recurrence rates due to frequent diagnosis at an …
Polyphenols in metabolic diseases
Polyphenols (PPs) are a large group of phytochemicals containing phenolic rings with two or
more hydroxyl groups. They possess powerful antioxidant properties, multiple therapeutic …
more hydroxyl groups. They possess powerful antioxidant properties, multiple therapeutic …
[HTML][HTML] Implications of hydrogen sulfide in colorectal cancer: Mechanistic insights and diagnostic and therapeutic strategies
H Lin, Y Yu, L Zhu, N Lai, L Zhang, Y Guo, X Lin… - Redox Biology, 2023 - Elsevier
Hydrogen sulfide (H 2 S) is an important signaling molecule in colorectal cancer (CRC). It is
produced in the colon by the catalytic synthesis of the colonocytes' enzymatic systems and …
produced in the colon by the catalytic synthesis of the colonocytes' enzymatic systems and …
[HTML][HTML] Reactive oxygen species and ovarian diseases: Antioxidant strategies
J Liang, Y Gao, Z Feng, B Zhang, Z Na, D Li - Redox Biology, 2023 - Elsevier
Reactive oxygen species (ROS) are mainly produced in mitochondria and are involved in
various physiological activities of the ovary through signaling and are critical for regulating …
various physiological activities of the ovary through signaling and are critical for regulating …
Natural products can be used in therapeutic management of COVID-19: Probable mechanistic insights
The unexpected emergence of the new Coronavirus disease (COVID-19) has affected more
than three hundred million individuals and resulted in more than five million deaths …
than three hundred million individuals and resulted in more than five million deaths …
Bax/Bcl-2 cascade is regulated by the EGFR pathway: therapeutic targeting of non-small cell lung cancer
Non-small cell lung carcinoma (NSCLC) comprises 80%–85% of lung cancer cases. EGFR
is involved in several cancer developments, including NSCLC. The EGFR pathway …
is involved in several cancer developments, including NSCLC. The EGFR pathway …
Characterization of two O-methyltransferases involved in the biosynthesis of O-methylated catechins in tea plant
JQ Jin, FR Qu, H Huang, QS Liu, MY Wei… - Nature …, 2023 - nature.com
Tea is known for having a high catechin content, with the main component being (−)-
epigallocatechin gallate (EGCG), which has significant bioactivities, including potential anti …
epigallocatechin gallate (EGCG), which has significant bioactivities, including potential anti …
Chemico-biological aspects of (−)-epigallocatechin-3-gallate (EGCG) to improve its stability, bioavailability and membrane permeability: Current status and future …
Natural products have been a bedrock for drug discovery for decades.(−)-Epigallocatechin-3-
gallate (EGCG) is one of the widely studied natural polyphenolic compounds derived from …
gallate (EGCG) is one of the widely studied natural polyphenolic compounds derived from …