Major insights into the phylogenetic distribution, biochemistry, and evolutionary significance
of organelles involved in ATP synthesis (energy metabolism) in eukaryotes that thrive in …

The pathogenic trypanosomatids Trypanosoma brucei, Trypanosoma cruzi, and Leishmania
spp. are the causative agents of African trypanosomiasis, Chagas disease, and …

Leishmania parasites alternate between extracellular promastigote stages in the insect
vector and an obligate intracellular amastigote stage that proliferates within the …

Trypanosoma brucei, as well as Trypanosoma cruzi and more than 20 species of the genus
Leishmania, form a group of flagellated protists that threaten human health. These …

Fermentation or anoxic metabolism allows unicellular organisms to colonize environments
that become anoxic. Free-living unicellular algae capable of a photoautotrophic lifestyle can …

The importance of mitochondria for a typical aerobic eukaryotic cell is undeniable, as the list
of necessary mitochondrial processes is steadily growing. Here, we summarize the current …

A set of benzophenone-derived bisphosphonium salts was synthesized and assayed for
lethal activity on the human protozoan parasite Leishmania. A subset of them, mostly …

Acquisition of energy is central to life. In addition to the synthesis of ATP, organisms need
energy for the establishment and maintenance of a transmembrane difference in …

Background The bloodstream forms of Trypanosoma brucei, the causative agent of sleeping
sickness, rely solely on glycolysis for ATP production. It is generally accepted that pyruvate …

Trypanosoma cruzi, the causative agent of Chagas disease, is an obligatory intracellular
parasite with a digenetic life cycle. Due to the variety of host environments, it faces several …