Errors in chromosome segregation during mitosis have been recognized as a hallmark of
tumor cells since the late 1800s, resulting in the long-standing hypothesis that mitotic …

The DNA damage response recognizes DNA lesions and coordinates a cell cycle arrest with
the repair of the damaged DNA, or removal of the affected cells to prevent the passage of …

Age-related accumulation of ploidy changes is associated with decreased expression of
genes controlling chromosome segregation and cohesin functions. To determine the …

Extensive damage to maternal DNA during meiosis causes infertility, birth defects and
abortions. However, it is unknown if fully grown oocytes have a mechanism to prevent the …

Mitotic defects leading to aneuploidy have been recognized as a hallmark of tumor cells for
over 100 years. Current data indicate that∼ 85% of human cancers have missegregated …

The DNA damage response (DDR) is critical for the maintenance of genetic stability and
serves as an anti-cancer barrier during early tumorigenesis. However, the role of the DDR in …

Telomeres and telomere-binding proteins form complex secondary nucleoprotein structures
that are critical for genome integrity but can present serious challenges during telomere …

Purpose: The catalytic function of BUB1 is required for chromosome arm resolution and
positioning of the chromosomal passenger complex for resolution of spindle attachment …

Aurora-B is a major kinase responsible for appropriate mitotic progression. Elevated
expression of Aurora-B has been frequently associated with several types of cancer …

The identification of clinically-relevant biomarkers is of upmost importance for the
management of cancer, from diagnosis to treatment choices. We performed a pan-cancer …