Periodontitis and risk of cancer: Mechanistic evidence

G Baima, M Minoli, DS Michaud, M Aimetti… - Periodontology …, 2024 - Wiley Online Library
This review aims to critically analyze the pathways of interaction and the pathogenic
mechanisms linking periodontitis and oral bacteria with the initiation/progression of cancer …

Intestinal flora and disease mutually shape the regional immune system in the intestinal tract

B Zhou, Y Yuan, S Zhang, C Guo, X Li, G Li… - Frontiers in …, 2020 - frontiersin.org
The intestinal tract is the largest digestive organ in the human body. It is colonized by, and
consistently exposed to, a myriad of microorganisms, including bifidobacteria, lactobacillus …

Fusobacterium nucleatum and its associated systemic diseases: epidemiologic studies and possible mechanisms

Z Fan, P Tang, C Li, Q Yang, Y Xu, C Su… - Journal of Oral …, 2023 - Taylor & Francis
Background Fusobacterium nucleatum (F. nucleatum) is an anaerobic oral commensal and
the major coaggregation bridge organism linking early and late colonisers. In recent years, a …

Gut microbiome: a promising biomarker for immunotherapy in colorectal cancer

S Temraz, F Nassar, R Nasr, M Charafeddine… - International journal of …, 2019 - mdpi.com
Research has been driven towards finding therapy predictive biomarkers for colorectal
cancer (CRC) with a special interest in studying the gut microbiome. Gut microbiome acts …

Cancer-associated fibroblasts derived extracellular vesicles promote angiogenesis of colorectal adenocarcinoma cells through miR-135b-5p/FOXO1 axis

X Dai, Y Xie, M Dong - Cancer Biology & Therapy, 2022 - Taylor & Francis
Colorectal adenocarcinoma (COAD) is a prevalent malignant tumor. Cancer-associated
fibroblasts (CAFs)-derived extracellular vesicles (EVs)(CAFs-EVs) are implicated in COAD …

Microbiota-immune interactions in ulcerative colitis and colitis associated cancer and emerging microbiota-based therapies

J Popov, V Caputi, N Nandeesha… - International journal of …, 2021 - mdpi.com
Ulcerative colitis (UC) is a chronic autoimmune disorder affecting the colonic mucosa. UC is
a subtype of inflammatory bowel disease along with Crohn's disease and presents with …

Cancer-associated fibroblasts-derived exosomes upregulate microRNA-135b-5p to promote colorectal cancer cell growth and angiogenesis by inhibiting thioredoxin …

H Yin, S Yu, Y Xie, X Dai, M Dong, C Sheng, J Hu - Cellular Signalling, 2021 - Elsevier
Objective The role of exosomes in human cancers has been identified, while the effect of
cancer-associated fibroblasts (CAFs)-derived exosomes (CAF-exos) transmitting microRNAs …

Fusobacterium nucleatum in the Colorectum and Its Association with Cancer Risk and Survival: A Systematic Review and Meta-analysis

C Gethings-Behncke, HG Coleman, HWT Jordao… - … Biomarkers & Prevention, 2020 - AACR
Background: The gut microbiome, in particular Fusobacterium nucleatum, has been reported
to play a role in colorectal cancer development and in patient prognosis. We aimed to …

Resolution of chronic inflammation and cancer

G Tezcan, N Yakar, H Hasturk, TE Van Dyke… - Periodontology …, 2024 - Wiley Online Library
Chronic inflammation poses challenges to effective cancer treatment. Although anti‐
inflammatory therapies have shown short‐term benefits, their long‐term implications may be …

Association or causation? Exploring the oral microbiome and cancer links

FRF Teles, F Alawi, RM Castilho… - Journal of Dental …, 2020 - journals.sagepub.com
Several epidemiological investigations have found associations between poor oral health
and different types of cancer, including colorectal, lung, pancreatic, and oral malignancies …