DNA is the molecule chosen by nature to store the information required to build organisms.
These organisms in turn serve to replicate that information. It was initially thought that DNA …

One of the best-studied DNA repair pathways is nucleotide excision repair, a process
consisting of DNA damage recognition, incision, excision, repair resynthesis, and DNA …

The nucleotide excision repair (NER) pathway removes helix-distorting lesions from DNA in
all organisms. Escherichia coli has long been a model for understanding NER, which is …

Nucleotide excision repair is the major DNA repair mechanism in all species tested. This
repair system is the sole mechanism for removing bulky adducts from DNA, but it repairs …

The uvrA, uvrB, and uvrC genes control excision repair in Escherichia coli. Cells with
mutations in any of these three genes cannot repair DNA by nucleotide excision. When the …

Human cells contain a protein that binds to UV-irradiated DNA with high affinity. This protein,
the damaged DNA-binding protein (DDB), is absent from some xeroderma pigmentosum …

The XPC− HR23B complex is a prime candidate for the initial damage recognition step
during global genome nucleotide excision repair. A specific interaction between the XPC …

The incision and excision steps of nucleotide excision repair in Escherichia coli are
mediated by ABC excinuclease, a multisubunit enzyme composed of three proteins, UvrA …

Sharlyn J. Mazur** and Lawrence Grossman* Department of Biochemistry, The Johns
Hopkins University School of Hygiene and Public Health, Baltimore, Maryland 21205 …

The UvrA, UvrB, and UvrC proteins collectively catalyze the dual incision of a damaged DNA
strand in an ATP-dependent reaction. We previously reported (Orren, DK, and Sancar …