The investigation of macromolecular biomolecules with ion mobility mass spectrometry (IM-
MS) techniques has provided substantial insights into the field of structural biology over the …

Gene regulation requires the dynamic coordination of hundreds of regulatory factors at
precise genomic and RNA targets. Although many regulatory factors have specific affinity for …

Genome sequencing projects have resulted in a rapid increase in the number of known
protein sequences. In contrast, only about one-hundredth of these sequences have been …

The molecular organization of eukaryotic nuclear volumes remains largely unexplored. Here
we combined recent developments in cryo–electron tomography (cryo-ET) to produce three …

Biomolecules are in constant motion. To understand how they function, and why
malfunctions can cause disease, it is necessary to describe their three-dimensional …

Proteins are essential molecular building blocks of life, responsible for most biological
functions as a result of their specific molecular interactions. However, predicting their …

Complex biological systems and cellular networks may underlie most genotype to
phenotype relationships. Here, we review basic concepts in network biology, discussing …

3D cryo-electron microscopy (cryo-EM) is an expanding structural biology technique that has
recently undergone a quantum leap progression in its achievable resolution and its …

Sample purity is central to in vitro studies of protein function and regulation, and to the
efficiency and success of structural studies using techniques such as x-ray crystallography …

Supramolecular protein assemblies are an emerging area within the chemical sciences,
which combine the topological structures of the field of supramolecular chemistry and the …