Lignans and Neolignans: Plant secondary metabolites as a reservoir of biologically active substances
F Zálešák, DJYD Bon, J Pospíšil - Pharmacological Research, 2019 - Elsevier
Lignans and neolignans are plant secondary metabolites derived from the oxidative
coupling of phenylpropanoids. Biological activity of these phenolic compounds ranges from …
coupling of phenylpropanoids. Biological activity of these phenolic compounds ranges from …
The potential of secondary metabolites from plants as drugs or leads against trypanosoma cruzi-an update from 2012 to 2021
H Barbosa, F Thevenard… - Current Topics in …, 2023 - ingentaconnect.com
Background: Chagas disease (American Trypanosomiasis) is classified by the World Health
Organization (WHO) as one of the seventeen neglected tropical diseases (NTD), affecting …
Organization (WHO) as one of the seventeen neglected tropical diseases (NTD), affecting …
Evaluating the Antischistosomal Activity of Dehydrodieugenol B and Its Methyl Ether Isolated from Nectandra leucantha─ A Preclinical Study against Schistosoma …
VC Rocha, RA Cajas, AI Andrade-de-Siqueira… - ACS …, 2023 - ACS Publications
Schistosomiasis, a parasitic disease affecting nearly 250 million individuals globally, poses
a significant health challenge. With praziquantel being the sole available treatment and its …
a significant health challenge. With praziquantel being the sole available treatment and its …
New derivatives from dehydrodieugenol B and its methyl ether displayed high anti-Trypanosoma cruzi activity and cause depolarization of the plasma membrane and …
TS Galhardo, AK Ueno, TA Costa-Silva… - Chemico-Biological …, 2022 - Elsevier
In the present work, dehydrodieugenol B (1) and its methyl ether (2), isolated from
Nectandra leucantha twigs, were used as starting material for the preparation of two new …
Nectandra leucantha twigs, were used as starting material for the preparation of two new …
Effects of Eugenol and Dehydrodieugenol B from Nectandra leucantha against Lipopolysaccharide (LPS)-Induced Experimental Acute Lung Inflammation
MI Bittencourt-Mernak, NM Pinheiro… - Journal of natural …, 2021 - ACS Publications
Acute lung injury (ALI) is an important public health problem. The present work investigated
whether dehydrodieugenol B treatment, a compound isolated from Brazilian plant Nectandra …
whether dehydrodieugenol B treatment, a compound isolated from Brazilian plant Nectandra …
A semi-synthetic neolignan derivative from dihydrodieugenol B selectively affects the bioenergetic system of Leishmania infantum and inhibits cell division
M Amaral, FS de Sousa, TAC Silva, AJG Junior… - Scientific Reports, 2019 - nature.com
Leishmaniasis is a neglected disease that affects more than 12 million people, with a limited
therapy. Plant-derived natural products represent a useful source of anti-protozoan …
therapy. Plant-derived natural products represent a useful source of anti-protozoan …
Antitrypanosomal activity and effect in plasma membrane permeability of (−)-bornyl p-coumarate isolated from Piper cernuum (Piperaceae)
TR Morais, TA Costa-Silva, DD Ferreira, BJ Novais… - Bioorganic …, 2019 - Elsevier
This work describes the isolation of six metabolites from leaves and branches of Piper
cernuum (Piperaceae):(−)-cubebin (1),(−)-hinokinin (2),(−)-kusunokinin (3), trans …
cernuum (Piperaceae):(−)-cubebin (1),(−)-hinokinin (2),(−)-kusunokinin (3), trans …
[HTML][HTML] Neolignans isolated from twigs of Nectandra leucantha Ness & Mart (Lauraceae) displayed in vitro antileishmanial activity
SS Grecco, TA Costa-Silva, FS Sousa… - Journal of Venomous …, 2018 - SciELO Brasil
Background: The therapeutic arsenal for the treatment of Leishmaniasis is limited and
includes toxic compounds (antimonials, amphotericin B, pentamidine and miltefosine) …
includes toxic compounds (antimonials, amphotericin B, pentamidine and miltefosine) …
Dehydrodieugenol B derivatives as antiparasitic agents: Synthesis and biological activity against Trypanosoma cruzi
DD Ferreira, FS Sousa, TA Costa-Silva… - European journal of …, 2019 - Elsevier
Chagas disease is a neglected protozoan disease that affects more than eight million
people in developing countries. Due to the limited number and toxicity profiles of therapies …
people in developing countries. Due to the limited number and toxicity profiles of therapies …
[HTML][HTML] Genotoxic and cytotoxic effects of neolignans isolated from Nectandra leucantha (Lauraceae)
In this work was evaluated the cytotoxic activity of dehydrodieugenol B (1) and
methyldehydrodieugenol B (2) isolated from Nectandra leucantha (Lauraceae) through …
methyldehydrodieugenol B (2) isolated from Nectandra leucantha (Lauraceae) through …