Genomic instability is a primary cause and fundamental feature of human cancer. However,
all cancer cell genotypes generally translate into several common pathophysiological …

Cholesterol/sphingolipid-rich membrane domains, known as lipid rafts or membrane rafts,
play a critical role in the compartmentalization of signaling pathways. Physical segregation …

Twenty-five years ago, the first mammalian Transient Receptor Potential Canonical (TRPC)
channel was cloned, opening the vast horizon of the TRPC field. Today, we know that there …

Store-operated calcium entry (SOCE) is a ubiquitous Ca 2+ entry pathway that is activated in
response to depletion of ER-Ca 2+ stores and critically controls the regulation of …

The calcium-activated chloride channel TMEM16A is intimately linked to cancers. Over
decades, TMEM16A over-expression and contribution to prognosis have been widely …

Cancer, the second cause of death worldwide, is characterized by several common criteria,
known as the “cancer hallmarks” such as unrestrained cell proliferation, cell death …

Transient receptor potential channels convey signaling information from a number of stimuli
to a wide variety of cellular functions, mainly by inducing changes in cytosolic Ca2+ …

Transient receptor potential (TRP) proteins form non-selective Ca2+ permeable channels
that contribute to the modulation of a number of physiological functions in a variety of cell …

Calcium ions (Ca2+) play an important role as second messengers in regulating a plethora
of physiological and pathological processes, including the progression of cancer. Several …

Chemotherapy-induced peripheral neuropathy is a frequent, disabling side effect of
anticancer drugs. Oxaliplatin, a platinum compound used in the treatment of advanced …