Scrapie is a naturally occurring transmissible spongiform encephalopathy (TSE) or prion
disease of sheep and goats. Scrapie is a protein misfolding disease where the normal prion …

Simple Summary Classical scrapie is a prionic, neurological, consumptive, and chronic
disease that affects naturally domestic small ruminants. It was initially described in the UK …

Atypical/Nor98 scrapie was first identified in 1998 in Norway. It is now considered as a
worldwide disease of small ruminants and currently represents a significant part of the …

Experimental obstacles have impeded our ability to study prion transmission within and,
more particularly, between species. Here, we used cervid prion protein expressed in brain …

Background The development of active surveillance programmes for transmissible
spongiform encephalopathies of small ruminants across Europe has led to the recent …

Prion diseases or transmissible spongiform encephalopathies (TSEs) are fatal protein-
misfolding neurodegenerative diseases. TSEs have been described in several species …

Transmissible spongiform encephalopaties (TSEs) are fatal neurodegenerative diseases
characterized by the aggregation and accumulation of the misfolded prion protein in the …

Prions are infectious agents that replicate through the autocatalytic misfolding of the cellular
prion protein (PrPC) into infectious aggregates (PrPSc) causing fatal neurodegenerative …

To investigate the possibility of oral transmission of atypical scrapie in sheep and determine
the distribution of infectivity in the animals' peripheral tissues, we challenged neonatal lambs …

In a consignment of sheep brains from New Zealand, to be used in Europe as negative
control material in scrapie rapid screening test evaluations, brain samples from 1 sheep (no …