Most cancer-associated deaths occur due to metastasis, yet our understanding of metastasis
as an evolving, heterogeneous, systemic disease and of how to effectively treat it is still …

Epithelial–mesenchymal transition (EMT) is an essential process in normal embryonic
development and tissue regeneration. However, aberrant reactivation of EMT is associated …

In recent years, exceptional technological advances have enabled the identification and
interrogation of rare circulating tumour cells (CTCs) from blood samples of patients, leading …

Circulating tumor cells (CTCs) are tumor cells that shed from the primary tumor and
intravasate into the peripheral blood circulation system responsible for metastasis. Sensitive …

The dynamic interactions of cancer cells with their microenvironment consisting of stromal
cells (cellular part) and extracellular matrix (ECM) components (non-cellular) is essential to …

Nasopharyngeal carcinoma (NPC) is a particular entity of head neck cancer that is generally
regarded as a genetic disease with diverse intertumor and intratumor heterogeneity. This …

Heterogeneity within a tumour increases its ability to adapt to constantly changing
constraints, but adversely affects a patient's prognosis, therapy response and clinical …

PURPOSE Our previously published findings reported that local consolidative therapy (LCT)
with radiotherapy or surgery improved progression-free survival (PFS) and delayed new …

Single-cell technologies have contributed to unravelling tumour heterogeneity, now
considered a hallmark of cancer and one of the main causes of tumour resistance to cancer …

Background Ovarian cancer (OC) is the most lethal gynecologic malignancy worldwide. One
of the main challenges in the management of OC is the late clinical presentation of disease …