Alpha-linolenic acid (ALA) is an essential fatty acid and the substrate for the synthesis of
longer-chain, more unsaturated ω-3 fatty acids, eicosapentaenoic acid (EPA) …

Background The remarkable growth of genome-wide association studies (GWAS) has
created a critical need to experimentally validate the disease-associated variants, 90% of …

In nonalcoholic fatty liver disease, hepatic gene expression and fatty acid (FA) composition
have been reported independently, but a comprehensive gene expression profiling in …

The aim of this review is to evaluate the effects of omega-3 long chain polyunsaturated fatty
acids (n-3 LCPUFA) supplementation in pregnant and lactating women and infants during …

Desaturase and elongase-limiting endogenous long-chain polyu... : Current Opinion in Clinical
Nutrition & Metabolic Care Desaturase and elongase-limiting endogenous long-chain …

Epidemiological studies on Greenland Inuits in the 1970s and subsequent human studies
have established an inverse relationship between the ingestion of omega-3 fatty acids [C 20 …

Localization of causal variants underlying known risk loci is one of the main research
challenges following genome-wide association studies. Risk loci are typically dissected …

Polyunsaturated fatty acids (PUFA) play pleiotropic and crucial roles in biological systems.
Both blood and tissue levels of PUFA are influenced not only by diet, but to a large extent …

Variants in the FADS gene cluster modify the activity of polyunsaturated fatty acid (PUFA)
desaturation and the lipid composition in human blood and tissue. FADS variants have been …

There is growing evidence that early nutrition affects later cognitive performance. The idea
that the diet of mothers, infants, and children could affect later mental performance has major …