An antibody's stability greatly influences its performance (ie its specificity and affinity). Thus,
stability is a major issue for researchers and manufacturers, especially with the increasing …

Protein aggregation in biotherapeutics has been identified to increase immunogenicity,
leading to immune-mediated adverse effects, such as severe allergic responses including …

Protein solubility is often an essential requirement in biotechnological and biomedical
applications. Great advances in understanding the principles that determine this specific …

Protein misfolding diseases are becoming increasingly prevalent, yet there are very few
effective pharmacological treatments. The onset and progression of these diseases is …

Characterizing the sizes and interactions of macromolecules under native conditions is a
challenging problem in many areas of molecular sciences, which fundamentally arises from …

The realization of an end‐to‐end integrated continuous lab‐scale process for monoclonal
antibody manufacturing is described. For this, a continuous cultivation with filter‐based cell …

Therapeutic antibody technology heavily dominates the biologics market and continues to
present as a significant industrial interest in developing novel and improved antibody …

Purpose To identify the aggregation mechanism and the stability characteristics of three
different monoclonal antibodies under acidic conditions. Methods The aggregation kinetics …

Monoclonal antibodies (mAbs) as a class of therapeutic molecules are finding an increasing
demand in the biotechnology industry for the treatment of diseases like cancer and multiple …

Colorectal cancer (CRC) is the third most common cancer and the second leading cause of
cancer deaths worldwide. Besides common therapeutic approaches, such as surgery …