[HTML][HTML] A surgically optimized intraoperative poly (I: C)-releasing hydrogel prevents cancer recurrence
Recurrences frequently occur following surgical removal of primary tumors. In many cancers,
adjuvant therapies have limited efficacy. Surgery provides access to the tumor …
adjuvant therapies have limited efficacy. Surgery provides access to the tumor …
[HTML][HTML] Histone lysine methyltransferase-related neurodevelopmental disorders: current knowledge and saRNA future therapies
Neurodevelopmental disorders encompass a group of debilitating diseases presenting with
motor and cognitive dysfunction, with variable age of onset and disease severity. Advances …
motor and cognitive dysfunction, with variable age of onset and disease severity. Advances …
[HTML][HTML] Gene editing and cardiac disease modelling for the interpretation of genetic variants of uncertain significance in congenital heart disease
Background Genomic sequencing in congenital heart disease (CHD) patients often
discovers novel genetic variants, which are classified as variants of uncertain significance …
discovers novel genetic variants, which are classified as variants of uncertain significance …
[HTML][HTML] CRISPR-Cas9-generated PTCHD1 2489T> G stem cells recapitulate patient phenotype when undergoing neural induction
Summary An estimated 3.5%–5.9% of the global population live with rare diseases, and
approximately 80% of these diseases have a genetic cause. Rare genetic diseases are …
approximately 80% of these diseases have a genetic cause. Rare genetic diseases are …
Reanalysis of Chromosomal Microarray Data Using a Smaller Copy Number Variant Call Threshold Identifies Four Cases with Heterozygous Multiexon Deletions of …
N Kubota, R Takeda, J Kobayashi, E Hidaka… - Molecular …, 2023 - karger.com
Introduction: Chromosomal microarray (CMA) is a highly accurate and established method
for detecting copy number variations (CNVs) in clinical genetic testing. CNVs are important …
for detecting copy number variations (CNVs) in clinical genetic testing. CNVs are important …
Establishment of Human Pluripotent Stem Cell-derived Cortical Neurosphere Model to Study Pathomechanisms and Drug Sensitivity in Kleefstra Syndrome
A Balogh, M Bódi-Jakus, VR Karl, T Bellák, B Széky… - 2024 - researchsquare.com
In the present study, we aimed to establish and characterize a mature cortical spheroid
model system for Kleefstra syndrome (KS) using patient-derived iPSC. We identified key …
model system for Kleefstra syndrome (KS) using patient-derived iPSC. We identified key …
[PDF][PDF] Biomaterial-assisted delivery of immunotherapy: a novel approach to prevent cancer recurrence
F Rwandamuriye - 2023 - research-repository.uwa.edu.au
Biomaterial-assisted delivery of immunotherapy: a novel approach to prevent cancer recurrence
Page 1 i Biomaterial-assisted delivery of immunotherapy: a novel approach to prevent cancer …
Page 1 i Biomaterial-assisted delivery of immunotherapy: a novel approach to prevent cancer …
[PDF][PDF] Investigating the Genetic Architecture of Juvenile Onset Common Complex Diseases
MK Tordoff - 2023 - pure.manchester.ac.uk
JIAU is the most common comorbidity of JIA, with around 13% of patients with JIA
developing the eye complication (Petty and Zheng, 2020). One recent study of 8066 children …
developing the eye complication (Petty and Zheng, 2020). One recent study of 8066 children …