HSPA8/HSC70 protein is a fascinating chaperone protein. It represents a constitutively
expressed, cognate protein of the HSP70 family, which is central in many cellular processes …

The endoplasmic reticulum (ER) is the site of membrane protein insertion, folding, and
assembly in eukaryotes. Over the past few years, a combination of genetic and biochemical …

Summary Tail-anchored (TA) proteins, defined by the presence of a single C-terminal
transmembrane domain (TMD), play critical roles throughout the secretory pathway and in …

Membrane proteins are inserted into the endoplasmic reticulum (ER) by two highly
conserved parallel pathways. The well-studied co-translational pathway uses signal …

The heterotrimeric Sec61 complex and the dimeric Sec62/Sec63 complex are located in the
membrane of the human endoplasmic reticulum (ER) and play a central role in translocation …

Hundreds of proteins are anchored in intracellular membranes by a single transmembrane
domain (TMD) close to the C terminus. Although these tail-anchored (TA) proteins serve …

Protein transport via the Sec translocon represents an evolutionary conserved mechanism
for delivering cytosolically-synthesized proteins to extra-cytosolic compartments. The Sec …

A large group of diverse, functionally important, and differently localized transmembrane
proteins, share a particular membrane topology, consisting of a cytosolic N-terminal region …

Co-translational transport of polypeptides into the endoplasmic reticulum (ER) involves the
Sec61 channel and additional components such as the ER lumenal Hsp70 BiP and its …

The spatial and temporal coordination of protein transport is an essential cornerstone of the
bacterial adaptation to different environmental conditions. By adjusting the protein …