microRNA-382 as a tumor suppressor? Roles in tumorigenesis and clinical significance
MicroRNAs (miRNAs) are small single-stranded RNAs belonging to a class of non-coding
RNAs with an average length of 18–22 nucleotides. Although not able to encode any …
RNAs with an average length of 18–22 nucleotides. Although not able to encode any …
Targeting age-related pathways in heart failure
During aging, deterioration in cardiac structure and function leads to increased susceptibility
to heart failure. The need for interventions to combat this age-related cardiac decline is …
to heart failure. The need for interventions to combat this age-related cardiac decline is …
[HTML][HTML] The role of microRNAs in human diseases
AM Ardekani, MM Naeini - Avicenna journal of medical …, 2010 - ncbi.nlm.nih.gov
MicroRNAs (miRNAs) are short RNA molecules which bind to target mRNAs, resulting in
translational repression and gene silencing and are found in all eukaryotic cells …
translational repression and gene silencing and are found in all eukaryotic cells …
Non-coding RNA
JS Mattick, IV Makunin - Human molecular genetics, 2006 - academic.oup.com
The term non-coding RNA (ncRNA) is commonly employed for RNA that does not encode a
protein, but this does not mean that such RNAs do not contain information nor have function …
protein, but this does not mean that such RNAs do not contain information nor have function …
A putative RNA-interference-based immune system in prokaryotes: computational analysis of the predicted enzymatic machinery, functional analogies with eukaryotic …
KS Makarova, NV Grishin, SA Shabalina, YI Wolf… - Biology direct, 2006 - Springer
Background All archaeal and many bacterial genomes contain Clustered Regularly
Interspaced Short Palindrome Repeats (CRISPR) and variable arrays of the CRISPR …
Interspaced Short Palindrome Repeats (CRISPR) and variable arrays of the CRISPR …
Clinical impact of serum exosomal microRNA‐21 as a clinical biomarker in human esophageal squamous cell carcinoma
Y Tanaka, H Kamohara, K Kinoshita, J Kurashige… - Cancer, 2013 - Wiley Online Library
BACKGROUND: Exosomes are 40‐nm to 100‐nm membrane vesicles that are secreted by
various cells, and they play a major role in cell‐cell communication. The objective of this …
various cells, and they play a major role in cell‐cell communication. The objective of this …
MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer
IA Asangani, SAK Rasheed, DA Nikolova, JH Leupold… - Oncogene, 2008 - nature.com
Tumor-suppressor Pdcd4 inhibits transformation and invasion and is downregulated in
cancers. So far, it has not been studied as to whether miRNAs, suppressing target …
cancers. So far, it has not been studied as to whether miRNAs, suppressing target …
Negative regulation of lncRNA GAS5 by miR-21
In addition to protein-coding genes, the human genome makes a large amount of noncoding
RNAs, including microRNAs and long noncoding RNAs (lncRNAs). Both microRNAs and …
RNAs, including microRNAs and long noncoding RNAs (lncRNAs). Both microRNAs and …
[HTML][HTML] A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen
To enable arrayed or pooled loss-of-function screens in a wide range of mammalian cell
types, including primary and nondividing cells, we are developing lentiviral short hairpin …
types, including primary and nondividing cells, we are developing lentiviral short hairpin …
miR-34a repression of SIRT1 regulates apoptosis
M Yamakuchi, M Ferlito… - Proceedings of the …, 2008 - National Acad Sciences
MicroRNA 34a (miR-34a) is a tumor suppressor gene, but how it regulates cell proliferation
is not completely understood. We now show that the microRNA miR-34a regulates silent …
is not completely understood. We now show that the microRNA miR-34a regulates silent …