Dopamine receptors are widely distributed within the brain where they play critical
modulator roles on motor functions, motivation and drive, as well as cognition. The …

Highlights•Humans and animals seek information about uncertain future
rewards.•Information is valued for resolving uncertainty and signaling desirable …

Striatal dopamine drives associative learning by acting as a teaching signal. Much work has
focused on simple learning paradigms, including Pavlovian and instrumental learning …

Dopamine is implicated in adaptive behavior through reward prediction error (RPE) signals
that update value estimates. There is also accumulating evidence that animals in structured …

Recent animal research indicates that dopamine and serotonin, neuromodulators
traditionally linked to appetitive and aversive processes, are also involved in sensory …

Different regions of the striatum regulate different types of behavior. However, how
dopamine signals differ across striatal regions and how dopamine regulates different …

Innate behaviors meet multiple needs adaptively and in a serial order, suggesting the
existence of a hitherto elusive brain dynamics that brings together representations of …

While there is emerging evidence of sex differences in decision-making behavior, the neural
substrates that underlie such differences remain largely unknown. Here we demonstrate that …

Two forms of associative learning—delay conditioning and trace conditioning—have been
widely investigated in humans and higher-order mammals. In delay conditioning, an …

Highlights•Computation noise drives human decision variability under uncertainty.•
Computation noise sets cognitive constraints on information processing.•Computation noise …