Our knowledge of pluripotent stem cell (PSC) biology has advanced to the point where we
now can generate most cells of the human body in the laboratory. PSC-derived …

Cardiovascular diseases are the leading cause of death worldwide. Therefore, the discovery
of induced pluripotent stem cells (iPSCs) and the subsequent generation of human induced …

The most common form of genetic heart disease is hypertrophic cardiomyopathy (HCM),
which is caused by variants in cardiac sarcomeric genes and leads to abnormal heart …

The immature physiology of cardiomyocytes derived from human induced pluripotent stem
cells (hiPSCs) limits their utility for drug screening and disease modelling. Here we show …

Pluripotent stem cell-derived organoids can recapitulate significant features of organ
development in vitro. We hypothesized that creating human heart organoids by mimicking …

Rationale: Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) are a readily
available, robustly reproducible, and physiologically appropriate human cell source for …

Pluripotent stem-cell-derived cardiomyocytes (PSC-CMs) provide an unprecedented
opportunity to study human heart development and disease, but they are functionally and …

Engineered human cardiac tissues facilitate progress in regenerative medicine, disease
modelling and drug development. In this Perspective, we reflect on the most notable …

How cells become specialized, or" mature," is important for cell and developmental biology.
While maturity is usually deemed a terminal fate, it may be more helpful to consider …

Current methods to differentiate cardiomyocytes from human pluripotent stem cells (PSCs)
inadequately recapitulate complete development and result in PSC-derived cardiomyocytes …