SUMMARY A major part of organismal complexity and versatility of prokaryotes resides in
their ability to fine-tune gene expression to adequately respond to internal and external …

Single-stranded DNA (ssDNA) binding proteins (SSBs) are critical in maintaining genome
stability by protecting the transient existence of ssDNA from damage during essential …

Abstract Knowledge of protein–DNA binding specificity has important implications in
understanding DNA metabolism, transcriptional regulation and developing therapeutic …

Proper cell functioning depends on the precise spatio-temporal expression of its genetic
material. Gene expression is controlled to a great extent by sequence-specific transcription …

Motivation: Template-based prediction of DNA binding proteins requires not only structural
similarity between target and template structures but also prediction of binding affinity …

ABSTRACT 3D-footprint is a living database, updated and curated on a weekly basis, which
provides estimates of binding specificity for all protein–DNA complexes available at the …

Quite often a single or a combination of protein mutations is linked to specific diseases.
However, distinguishing from sequence information which mutations have real effects in the …

Transcription factor binding sites (TFBSs) are DNA sequences of 6–15 base pairs.
Interaction of these TFBSs with transcription factors (TFs) is largely responsible for most …

Proteins are the bricks and mortar of cells, playing structural and functional roles. In order to
perform their function, they interact with each other as well as with other biomolecules such …

Recognition of genomic binding sites by transcription factors can occur through base-
specific recognition, or by recognition of variations within the structure of the DNA …