[HTML][HTML] Treatment strategies for cryptococcal infection: challenges, advances and future outlook

KR Iyer, NM Revie, C Fu, N Robbins… - Nature Reviews …, 2021 - nature.com
Cryptococcus spp., in particular Cryptococcus neoformans and Cryptococcus gattii, have an
enormous impact on human health worldwide. The global burden of cryptococcal meningitis …

The antifungal pipeline: a reality check

JR Perfect - Nature reviews Drug discovery, 2017 - nature.com
Invasive fungal infections continue to appear in record numbers as the
immunocompromised population of the world increases, owing partially to the increased …

Cryptococcosis

EK Maziarz, JR Perfect - Infectious disease clinics, 2016 - id.theclinics.com
Cryptococcosis is an infectious disease with worldwide distribution and wide array of clinical
presentations caused by pathogenic encapsulated yeasts in the genus Cryptococcus …

Pulmonary cryptococcosis: a review of pathobiology and clinical aspects

F Setianingrum, R Rautemaa-Richardson… - Medical …, 2019 - academic.oup.com
Pulmonary cryptococcosis is an important opportunistic invasive mycosis in
immunocompromised patients, but it is also increasingly seen in immunocompetent patients …

[HTML][HTML] Vaccines for human fungal diseases: close but still a long way to go

LVN Oliveira, R Wang, CA Specht, SM Levitz - npj Vaccines, 2021 - nature.com
Despite the substantial global burden of human fungal infections, there are no approved
fungal vaccines to protect at risk individuals. Here, we review the progress that has been …

[HTML][HTML] Induction of memory-like dendritic cell responses in vivo

CR Hole, CML Wager, N Castro-Lopez… - Nature …, 2019 - nature.com
Dendritic cells (DCs), a vital component of the innate immune system, are considered to lack
antigen specificity and be devoid of immunological memory. Strategies that can induce …

[HTML][HTML] Pathogenic fungal infection in the lung

Z Li, G Lu, G Meng - Frontiers in immunology, 2019 - frontiersin.org
Respiratory fungal infection is a severe clinical problem, especially in patients with
compromised immune functions. Aspergillus, Cryptococcus, Pneumocystis, and endemic …

New pathogens, new tricks: emerging, drug‐resistant fungal pathogens and future prospects for antifungal therapeutics

J Geddes‐McAlister, RS Shapiro - … of the New York Academy of …, 2019 - Wiley Online Library
Fungal pathogens are a growing threat to public health. As human immunodeficiency
becomes increasingly common, fungal infections are becoming more prevalent. The use of …

Antifungal drugs: New insights in research & development

AM Nicola, P Albuquerque, HC Paes… - Pharmacology & …, 2019 - Elsevier
The need for better antifungal therapy is commonly accepted in view of the high mortality
rates associated with systemic infections, the low number of available antifungal classes …

[HTML][HTML] Fungal vaccines, mechanism of actions and immunology: A comprehensive review

S Nami, R Mohammadi, M Vakili, K Khezripour… - Biomedicine & …, 2019 - Elsevier
Fungal infections include a wide range of opportunistic and invasive diseases. Two of four
major fatal diseases in patients with human immunodeficiency virus (HIV) infection are …