Background We have previously reported successful induction of renal allograft tolerance in
nonhuman primates (NHP) after an initial posttransplant period of conventional …

Heart transplantation is the only long-lasting lifesaving option for patients with terminal
cardiac failure. The number of available human organs is however far below the actual …

Blockade of the CD40/CD154 T cell costimulation pathway is a promising approach to
supplement or replace current clinical immunosuppression in solid organ transplantation …

The blockade of the CD40/CD40L immune checkpoint is considered essential for cardiac
xenotransplantation. However, it is still unclear which single antibody directed against CD40 …

The promising outcomes of immune‐checkpoint based immunotherapies in cancer have
provided a proportional perspective ahead of exploiting similar approaches in …

The National Institutes of Health (NIH) has long supported using nonhuman primate (NHP)
models for research on kidney, pancreatic islet, heart, and lung transplantation. The primary …

Effective immune responses require antigen presentation by major histocompatibility
complexes with cognate T-cell receptor and antigen-independent costimulatory signaling for …

Background We have previously reported successful induction of renal allograft tolerance in
nonhuman primates (NHP) after an initial posttransplant period of conventional …

Background Xenotransplantation has made significant advances recently using pigs
genetically engineered to remove carbohydrate antigens, either alone or with addition of …

More than 37,000 patients underwent solid organ transplantation in the United States in
2017. A life-saving procedure, transplantation carries with it the need for lifelong …