PI3K/AKT/mTOR dysregulation and reprogramming metabolic pathways in renal cancer: Crosstalk with the VHL/HIF axis
Renal cell carcinoma (RCC) represents 85–95% of kidney cancers and is the most frequent
type of renal cancer in adult patients. It accounts for 3% of all cancer cases and is in 7th …
type of renal cancer in adult patients. It accounts for 3% of all cancer cases and is in 7th …
Advances in the clinical management of high‐risk Wilms tumors
MV Ortiz, C Koenig, AE Armstrong, J Brok… - Pediatric blood & …, 2023 - Wiley Online Library
Outcomes are excellent for the majority of patients with Wilms tumors (WT). However, there
remain WT subgroups for which the survival rate is approximately 50% or lower …
remain WT subgroups for which the survival rate is approximately 50% or lower …
Hallmark discoveries in the biology of Wilms tumour
D Perotti, RD Williams, J Wegert, J Brzezinski… - Nature Reviews …, 2024 - nature.com
The modern study of Wilms tumour was prompted nearly 50 years ago, when Alfred
Knudson proposed the 'two-hit'model of tumour development. Since then, the efforts of …
Knudson proposed the 'two-hit'model of tumour development. Since then, the efforts of …
Gene expression studies of WT1 mutant Wilms tumor cell lines in the frame work of published kidney development data reveals their early kidney stem cell origin
B Royer-Pokora, W Wruck, J Adjaye, M Beier - Plos one, 2023 - journals.plos.org
In order to get a better insight into the timing of WT1 mutant Wilms tumor development, we
compared the gene expression profiles of nine established WT1 mutant Wilms tumor cell …
compared the gene expression profiles of nine established WT1 mutant Wilms tumor cell …
Targeting TRIP13 in favorable histology Wilms tumor with nuclear export inhibitors synergizes with doxorubicin
Wilms tumor (WT) is the most common renal malignancy of childhood. Despite
improvements in the overall survival, relapse occurs in~ 15% of patients with favorable …
improvements in the overall survival, relapse occurs in~ 15% of patients with favorable …
Insights into Personalized Care Strategies for Wilms Tumor: A Narrative Literature Review
Wilms tumor (WT), or nephroblastoma, is the predominant renal malignancy in the pediatric
population. This narrative review explores the evolution of personalized care strategies for …
population. This narrative review explores the evolution of personalized care strategies for …
[HTML][HTML] A multidisciplinary hyper-modeling scheme in personalized in silico oncology: coupling cell kinetics with metabolism, signaling networks, and biomechanics …
The massive amount of human biological, imaging, and clinical data produced by multiple
and diverse sources necessitates integrative modeling approaches able to summarize all …
and diverse sources necessitates integrative modeling approaches able to summarize all …
Stem cell signaling in nephroblastoma with reference to Wilms tumor
R Mythreyi, R Bharadwaj, A Panigrahi… - Cancer Stem Cells and …, 2024 - Elsevier
Stem cells are the group of cells that has the potential of differentiating into any type of cells.
Recent decades have witnessed the application of stem cells in medicine and therapies …
Recent decades have witnessed the application of stem cells in medicine and therapies …
Targeting TRIP13 in Wilms tumor with nuclear export inhibitors
Wilms tumor (WT) is the most common renal malignancy of childhood. Despite
improvements in the overall survival, relapse occurs in~ 15% of patients with favorable …
improvements in the overall survival, relapse occurs in~ 15% of patients with favorable …
Transcriptional fidelity enhances cancer cell line selection in pediatric cancers
Multi-omic technologies have allowed for comprehensive profiling of patient-derived tumor
samples and the cell lines that are intended to model them. Yet, our understanding of how …
samples and the cell lines that are intended to model them. Yet, our understanding of how …