The exosome-mediated PI3K/Akt/mTOR signaling pathway in neurological diseases

A Iranpanah, L Kooshki, SZ Moradi, L Saso, S Fakhri… - Pharmaceutics, 2023 - mdpi.com
As major public health concerns associated with a rapidly growing aging population,
neurodegenerative diseases (NDDs) and neurological diseases are important causes of …

Exosomes combined with biomaterials in the treatment of spinal cord injury

X Zhang, W Jiang, Y Lu, T Mao, Y Gu, D Ju… - … in Bioengineering and …, 2023 - frontiersin.org
Spinal cord injury (SCI) is a serious and disabling disease with a high mortality rate. It often
leads to complete or partial sensory and motor dysfunction and is accompanied by a series …

Schwann cell-derived exosomes and methylprednisolone composite patch for spinal cord injury repair

B Zhu, G Gu, J Ren, X Song, J Li, C Wang, W Zhang… - ACS …, 2023 - ACS Publications
Spinal cord injury (SCI) can cause permanent loss of sensory and motor function, and there
is no effective clinical treatment, to date. Due to the complex pathological process involved …

Schwann cell-derived exosomes containing MFG-E8 modify macrophage/microglial polarization for attenuating inflammation via the SOCS3/STAT3 pathway after …

J Ren, B Zhu, G Gu, W Zhang, J Li, H Wang… - Cell death & …, 2023 - nature.com
Macrophage/microglia polarization acts as an important part in regulating inflammatory
responses in spinal cord injury (SCI). However, the regulation of inflammation of Schwann …

Schwann cell-derived exosomal vesicles: a promising therapy for the injured spinal cord

M Ghosh, DD Pearse - International Journal of Molecular Sciences, 2023 - mdpi.com
Exosomes are nanoscale-sized membrane vesicles released by cells into their extracellular
milieu. Within these nanovesicles reside a multitude of bioactive molecules, which …

Schwann cells-derived exosomes promote functional recovery after spinal cord injury by promoting angiogenesis

JH Huang, YN Chen, H He, CH Fu, ZY Xu… - Frontiers in Cellular …, 2023 - frontiersin.org
Exosomes are small vesicles that contain diverse miRNA, mRNA, and proteins that are
secreted by multiple cells, and play a vital function in cell–cell communication. Numerous …

Exosomes as therapeutic and drug delivery vehicle for neurodegenerative diseases

Z Nouri, A Barfar, S Perseh, H Motasadizadeh… - Journal of …, 2024 - Springer
Neurodegenerative disorders are complex, progressive, and life-threatening. They cause
mortality and disability for millions of people worldwide. Appropriate treatment for …

Exosomes derived from schwann cells alleviate mitochondrial dysfunction and necroptosis after spinal cord injury via AMPK signaling pathway-mediated mitophagy

B Xu, Z Zhou, J Fang, J Wang, K Tao, J Liu… - Free Radical Biology and …, 2023 - Elsevier
Although spinal cord injury (SCI) represents a primary etiology of disability, currently, there
are exist limited viable therapies modalities. Acquiring comprehension of the diverse …

Exosome-mediated repair of spinal cord injury: a promising therapeutic strategy

T Yu, LL Yang, Y Zhou, MF Wu, JH Jiao - Stem Cell Research & Therapy, 2024 - Springer
Spinal cord injury (SCI) is a catastrophic injury to the central nervous system (CNS) that can
lead to sensory and motor dysfunction, which seriously affects patients' quality of life and …

Schwann cell‐derived exosomes promote lung cancer progression via miRNA‐21‐5p

Y Zhou, Y Zhang, J Xu, Y Wang, Y Yang, W Wang… - Glia, 2024 - Wiley Online Library
Schwann cells (SCs), the primary glial cells of the peripheral nervous system, which have
been identified in many solid tumors, play an important role in cancer development and …