[HTML][HTML] Selective COX-2 inhibitors: a review of their structure-activity relationships
A Zarghi, S Arfaei - Iranian journal of pharmaceutical research …, 2011 - ncbi.nlm.nih.gov
Non-steroidal anti-inflammatory drugs (NSAIDs) are the competitive inhibitors of
cyclooxygenase (COX), the enzyme which mediates the bioconversion of arachidonic acid …
cyclooxygenase (COX), the enzyme which mediates the bioconversion of arachidonic acid …
Progress in COX-2 inhibitors: a journey so far
AK Chakraborti, SK Garg, R Kumar… - Current medicinal …, 2010 - ingentaconnect.com
The non-steroidal anti-inflammatory drugs (NSAIDs) are diverse group of compounds used
for the treatment of inflammation, since the introduction of acetylsalicylic acid in 1899 …
for the treatment of inflammation, since the introduction of acetylsalicylic acid in 1899 …
Supported protic acid-catalyzed synthesis of 2, 3-disubstituted thiazolidin-4-ones: enhancement of the catalytic potential of protic acid by adsorption on solid supports
The catalytic potential of various protic acids has been assessed for the one pot tandem
condensation–cyclisation reaction involving an aldehyde, an amine, and thioglycolic acid to …
condensation–cyclisation reaction involving an aldehyde, an amine, and thioglycolic acid to …
Design, synthesis and biological screening of new 4-thiazolidinone derivatives with promising COX-2 selectivity, anti-inflammatory activity and gastric safety profile
Two series of new thiazolidin-4-one derivatives 4a–c and 8a–e were designed and
prepared. All the synthesized compounds were evaluated for their in vitro COX-2 selectivity …
prepared. All the synthesized compounds were evaluated for their in vitro COX-2 selectivity …
Discovery and optimization of 2, 3-diaryl-1, 3-thiazolidin-4-one-based derivatives as potent and selective cytotoxic agents with anti-inflammatory activity
Several studies have indicated the potential therapeutic outcomes of combining selective
COX-2 inhibitors with tubulin-targeting anticancer agents. In the current study, a novel series …
COX-2 inhibitors with tubulin-targeting anticancer agents. In the current study, a novel series …
3-Methyl-2-phenyl-1-substituted-indole derivatives as indomethacin analogs: design, synthesis and biological evaluation as potential anti-inflammatory and analgesic …
In a new group of 3-methyl-2-phenyl-1-substituted-indole derivatives (10a–f), the
indomethacin analogs were prepared via the Fisher indole synthesis reaction of …
indomethacin analogs were prepared via the Fisher indole synthesis reaction of …
Dual COX-2/15-LOX inhibitors: A new avenue in the prevention of cancer
A Aliabadi, E Khanniri, M Mahboubi-Rabbani… - European journal of …, 2023 - Elsevier
Abstract Dual cyclooxygenase 2/15-lipoxygenase inhibitors constitute a valuable alternative
to classical non-steroidal anti-inflammatory drugs (NSAIDs) and selective COX-2 …
to classical non-steroidal anti-inflammatory drugs (NSAIDs) and selective COX-2 …
Ionic liquid mediated and promoted eco-friendly preparation of thiazolidinone and pyrimidine nucleoside–thiazolidinone hybrids and their antiparasitic activities
X Zhang, X Li, D Li, G Qu, J Wang, PM Loiseau… - Bioorganic & medicinal …, 2009 - Elsevier
Without any catalyst, 2, 3-disubstituted-1, 3-thiazolidin-4-one derivatives were synthesized
efficiently via the three-component reaction of aldehyde, amine and mercaptoacetic acid in …
efficiently via the three-component reaction of aldehyde, amine and mercaptoacetic acid in …
Molecular modeling, synthesis and screening of some new 4-thiazolidinone derivatives with promising selective COX-2 inhibitory activity
In order to develop new selective cyclooxygenase-2 inhibitors, a series of novel 2-aryl-3-(4-
sulfamoyl/methylsulfonylphenylamino)-4-thiazolidinones were designed. Molecular …
sulfamoyl/methylsulfonylphenylamino)-4-thiazolidinones were designed. Molecular …
Recent advances in synthetic strategies and SAR of thiazolidin-4-one containing molecules in cancer therapeutics
A Sharma, D Sharma, N Saini, SV Sharma… - Cancer and Metastasis …, 2023 - Springer
Cancer is one of the life-threatening diseases accountable for millions of demises globally.
The inadequate effectiveness of the existing chemotherapy and its harmful effects has …
The inadequate effectiveness of the existing chemotherapy and its harmful effects has …